Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts

Markus Mullner, Dharmini Mehta, Cameron Nowell, Christopher John Porter

Research output: Contribution to journalArticleOtherpeer-review

16 Citations (Scopus)

Abstract

The shape-persistent nature and conformation of cylindrical polymer brushes (CPBs) present opportunities to explore the properties of anisotropic (i.e. non spherical) nanomaterials in biological settings. This study shows that CPBs with lengths of up to 1 μm are able to passively target tumours via the enhanced permeation and retention (EPR) effect. Moreover, large CPBs with higher aspect ratios (ARs) were able to penetrate tumours with similar efficiencies to much smaller systems with lower ARs.
Original languageEnglish
Pages (from-to)9121-9124
Number of pages4
JournalChemical Communications
Volume52
Issue number58
DOIs
Publication statusPublished - Mar 2016

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