Abstract
We describe the case of an adult male patient with AIDS who presented with severe anemia and on investigation was found to have red cell aplasia due to parvovirus B19 infection. Bone marrow examination revealed absence of erythroid development and rare giant pronormoblasts. Repeated serological examinations revealed a low level of parvovirus IgM but no IgG. Viremia was demonstrated by electron microscopy and by the polymerase chain reaction (PCR). The patient's initial hemoglobin was 45 g/l and over a four month period he required twenty units of blood. He was treated with intravenous immunoglobulin (Intragam, CSL) at a dose of 400 mg/kg/day for five days. This led to an increase in his hemoglobin to 135 g/l. Parvovirus remained detectable by PCR but not by electron microscopy. Six months later the patient relapsed (Hb 65 g/l). Again he was transfused and treated with intravenous immunoglobulin for five days. His hemoglobin rose to 153 g/l and remained stable. He subsequently received maintenance treatment with 30 g of intagram once a month. We recommend that parvovirus be considered in any HIV infected patient with recurrent anemia.
| Original language | English |
|---|---|
| Pages (from-to) | 277-280 |
| Number of pages | 4 |
| Journal | Pathology |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1996 |
| Externally published | Yes |
Keywords
- AIDS
- Immunoglobulin
- Parvovirus B19
- Red cell aplasia
Cite this
}
Parvovirus B19 in HIV infection : A treatable cause of anemia. / Fuller, Andrew; Moaven, Len; Spelman, Denis; Spicer, W. John; Wraight, Howard; Curtis, David; Leydon, Jenny; Doultree, Jennifer; Locarnini, Stephen.
In: Pathology, Vol. 28, No. 3, 1996, p. 277-280.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Parvovirus B19 in HIV infection
T2 - A treatable cause of anemia
AU - Fuller, Andrew
AU - Moaven, Len
AU - Spelman, Denis
AU - Spicer, W. John
AU - Wraight, Howard
AU - Curtis, David
AU - Leydon, Jenny
AU - Doultree, Jennifer
AU - Locarnini, Stephen
PY - 1996
Y1 - 1996
N2 - We describe the case of an adult male patient with AIDS who presented with severe anemia and on investigation was found to have red cell aplasia due to parvovirus B19 infection. Bone marrow examination revealed absence of erythroid development and rare giant pronormoblasts. Repeated serological examinations revealed a low level of parvovirus IgM but no IgG. Viremia was demonstrated by electron microscopy and by the polymerase chain reaction (PCR). The patient's initial hemoglobin was 45 g/l and over a four month period he required twenty units of blood. He was treated with intravenous immunoglobulin (Intragam, CSL) at a dose of 400 mg/kg/day for five days. This led to an increase in his hemoglobin to 135 g/l. Parvovirus remained detectable by PCR but not by electron microscopy. Six months later the patient relapsed (Hb 65 g/l). Again he was transfused and treated with intravenous immunoglobulin for five days. His hemoglobin rose to 153 g/l and remained stable. He subsequently received maintenance treatment with 30 g of intagram once a month. We recommend that parvovirus be considered in any HIV infected patient with recurrent anemia.
AB - We describe the case of an adult male patient with AIDS who presented with severe anemia and on investigation was found to have red cell aplasia due to parvovirus B19 infection. Bone marrow examination revealed absence of erythroid development and rare giant pronormoblasts. Repeated serological examinations revealed a low level of parvovirus IgM but no IgG. Viremia was demonstrated by electron microscopy and by the polymerase chain reaction (PCR). The patient's initial hemoglobin was 45 g/l and over a four month period he required twenty units of blood. He was treated with intravenous immunoglobulin (Intragam, CSL) at a dose of 400 mg/kg/day for five days. This led to an increase in his hemoglobin to 135 g/l. Parvovirus remained detectable by PCR but not by electron microscopy. Six months later the patient relapsed (Hb 65 g/l). Again he was transfused and treated with intravenous immunoglobulin for five days. His hemoglobin rose to 153 g/l and remained stable. He subsequently received maintenance treatment with 30 g of intagram once a month. We recommend that parvovirus be considered in any HIV infected patient with recurrent anemia.
KW - AIDS
KW - Immunoglobulin
KW - Parvovirus B19
KW - Red cell aplasia
UR - http://www.scopus.com/inward/record.url?scp=0030431071&partnerID=8YFLogxK
U2 - 10.1080/00313029600169154
DO - 10.1080/00313029600169154
M3 - Article
C2 - 8912362
AN - SCOPUS:0030431071
VL - 28
SP - 277
EP - 280
JO - Pathology
JF - Pathology
SN - 0031-3025
IS - 3
ER -