Partly-PEGylated poly-L-lysine dendrimers have reduced plasma stability and circulation times compared with fully PEGylated dendrimers

Lisa Michelle Kaminskas, Zemin Wu, Nick Barlow, Guy Yeoman Krippner, Benjamin James Boyd, Christopher John H Porter

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)


The current study was performed to examine the effect of 50 surface PEGylation on the plasma circulation, biodistribution and metabolism of intravenously administered Generation 4 poly-L-lysine dendrimers in rats. Partial surface PEGylation blocked the rapid and extensive vascular binding previusly described for the non-PEGylated dendrimer and slowed metabolism of the core, however the effect was less than that observed for total surface covergae of PEG. Capping the residual surface amines with acetyl groups further improved plasma stability.
Original languageEnglish
Pages (from-to)3871 - 3875
Number of pages5
JournalJournal of Pharmaceutical Sciences
Issue number10
Publication statusPublished - 2009

Cite this