TY - JOUR
T1 - Partly-PEGylated poly-L-lysine dendrimers have reduced plasma stability and circulation times compared with fully PEGylated dendrimers
AU - Kaminskas, Lisa Michelle
AU - Wu, Zemin
AU - Barlow, Nick
AU - Krippner, Guy Yeoman
AU - Boyd, Benjamin James
AU - Porter, Christopher John H
PY - 2009
Y1 - 2009
N2 - The current study was performed to examine the effect of 50 surface PEGylation on the plasma circulation, biodistribution and metabolism of intravenously administered Generation 4 poly-L-lysine dendrimers in rats. Partial surface PEGylation blocked the rapid and extensive vascular binding previusly described for the non-PEGylated dendrimer and slowed metabolism of the core, however the effect was less than that observed for total surface covergae of PEG. Capping the residual surface amines with acetyl groups further improved plasma stability.
AB - The current study was performed to examine the effect of 50 surface PEGylation on the plasma circulation, biodistribution and metabolism of intravenously administered Generation 4 poly-L-lysine dendrimers in rats. Partial surface PEGylation blocked the rapid and extensive vascular binding previusly described for the non-PEGylated dendrimer and slowed metabolism of the core, however the effect was less than that observed for total surface covergae of PEG. Capping the residual surface amines with acetyl groups further improved plasma stability.
UR - http://www3.interscience.wiley.com/journal/122255954/abstract?CRETRY=1&SRETRY=0
M3 - Article
SN - 0022-3549
VL - 98
SP - 3871
EP - 3875
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 10
ER -