Particulate matter air pollution, physical activity and systemic inflammation in Taiwanese adults

Zilong Zhang, Gerard Hoek, Ly yun Chang, Ta Chien Chan, Cui Guo, Yuan Chieh Chuang, Jimmy Chan, Changqing Lin, Wun Kai Jiang, Yuming Guo, Roel Vermeulen, Eng kiong Yeoh, Tony Tam, Alexis K.H. Lau, Sian Griffiths, Xiang Qian Lao

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

Background The protective effects of physical activity (PA) against chronic disease can be partially ascribed to its anti-inflammatory effects. On the other hand, long-term exposure to particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5) may induce systemic inflammation. Objective To investigate the joint effects of habitual PA and long-term exposure to PM2.5 on systemic inflammation in a large cohort of Taiwanese adults. Methods We studied 359,067 adult participants from a cohort consisting of Taiwanese residents who participated in a standard medical examination program from 2001 to 2014. Peripheral white blood cell (WBC) and differential counts were measured as indicators of systemic inflammation. Two-year average concentration of PM2.5 was estimated at each participant's address using a satellite-based spatio-temporal model. Habitual PA level was assessed by questionnaire (inactive, low, moderate and high). Mixed-effects linear regression model was used to examine the associations of WBC counts with PM2.5 and PA. Results Compared with inactive participants, those with low, moderate or high PA levels had 0.36% [95% confidence interval (CI): 0.31%, 0.41%], 0.70% (95%CI: 0.65%, 0.76%) and 1.16% (95%CI: 1.11%, 1.22%) lower WBC counts, respectively, after adjusting for PM2.5 exposure and a wide range of confounders. Long-term PM2.5 exposure was associated with increased WBC counts at all PA levels. Analyses for differential counts generated similar results. No significant interaction was observed between PA and PM2.5 exposure (P for interaction = 0.59). Conclusions Habitual PA was associated with statistically significant lower markers of systemic inflammation across different levels of PM2.5. Effects of PA and PM2.5 exposure on systemic inflammation are independent.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalInternational Journal of Hygiene and Environmental Health
Volume221
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Particulate matter
  • Physical activity
  • Systemic inflammation
  • White blood cell

Cite this

Zhang, Zilong ; Hoek, Gerard ; Chang, Ly yun ; Chan, Ta Chien ; Guo, Cui ; Chuang, Yuan Chieh ; Chan, Jimmy ; Lin, Changqing ; Jiang, Wun Kai ; Guo, Yuming ; Vermeulen, Roel ; Yeoh, Eng kiong ; Tam, Tony ; Lau, Alexis K.H. ; Griffiths, Sian ; Lao, Xiang Qian. / Particulate matter air pollution, physical activity and systemic inflammation in Taiwanese adults. In: International Journal of Hygiene and Environmental Health. 2018 ; Vol. 221, No. 1. pp. 41-47.
@article{c6a90df9b5224204ac624d48a995dbb3,
title = "Particulate matter air pollution, physical activity and systemic inflammation in Taiwanese adults",
abstract = "Background The protective effects of physical activity (PA) against chronic disease can be partially ascribed to its anti-inflammatory effects. On the other hand, long-term exposure to particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5) may induce systemic inflammation. Objective To investigate the joint effects of habitual PA and long-term exposure to PM2.5 on systemic inflammation in a large cohort of Taiwanese adults. Methods We studied 359,067 adult participants from a cohort consisting of Taiwanese residents who participated in a standard medical examination program from 2001 to 2014. Peripheral white blood cell (WBC) and differential counts were measured as indicators of systemic inflammation. Two-year average concentration of PM2.5 was estimated at each participant's address using a satellite-based spatio-temporal model. Habitual PA level was assessed by questionnaire (inactive, low, moderate and high). Mixed-effects linear regression model was used to examine the associations of WBC counts with PM2.5 and PA. Results Compared with inactive participants, those with low, moderate or high PA levels had 0.36{\%} [95{\%} confidence interval (CI): 0.31{\%}, 0.41{\%}], 0.70{\%} (95{\%}CI: 0.65{\%}, 0.76{\%}) and 1.16{\%} (95{\%}CI: 1.11{\%}, 1.22{\%}) lower WBC counts, respectively, after adjusting for PM2.5 exposure and a wide range of confounders. Long-term PM2.5 exposure was associated with increased WBC counts at all PA levels. Analyses for differential counts generated similar results. No significant interaction was observed between PA and PM2.5 exposure (P for interaction = 0.59). Conclusions Habitual PA was associated with statistically significant lower markers of systemic inflammation across different levels of PM2.5. Effects of PA and PM2.5 exposure on systemic inflammation are independent.",
keywords = "Particulate matter, Physical activity, Systemic inflammation, White blood cell",
author = "Zilong Zhang and Gerard Hoek and Chang, {Ly yun} and Chan, {Ta Chien} and Cui Guo and Chuang, {Yuan Chieh} and Jimmy Chan and Changqing Lin and Jiang, {Wun Kai} and Yuming Guo and Roel Vermeulen and Yeoh, {Eng kiong} and Tony Tam and Lau, {Alexis K.H.} and Sian Griffiths and Lao, {Xiang Qian}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.ijheh.2017.10.001",
language = "English",
volume = "221",
pages = "41--47",
journal = "International Journal of Hygiene and Environmental Health",
issn = "1438-4639",
publisher = "Elsevier",
number = "1",

}

Zhang, Z, Hoek, G, Chang, LY, Chan, TC, Guo, C, Chuang, YC, Chan, J, Lin, C, Jiang, WK, Guo, Y, Vermeulen, R, Yeoh, EK, Tam, T, Lau, AKH, Griffiths, S & Lao, XQ 2018, 'Particulate matter air pollution, physical activity and systemic inflammation in Taiwanese adults', International Journal of Hygiene and Environmental Health, vol. 221, no. 1, pp. 41-47. https://doi.org/10.1016/j.ijheh.2017.10.001

Particulate matter air pollution, physical activity and systemic inflammation in Taiwanese adults. / Zhang, Zilong; Hoek, Gerard; Chang, Ly yun; Chan, Ta Chien; Guo, Cui; Chuang, Yuan Chieh; Chan, Jimmy; Lin, Changqing; Jiang, Wun Kai; Guo, Yuming; Vermeulen, Roel; Yeoh, Eng kiong; Tam, Tony; Lau, Alexis K.H.; Griffiths, Sian; Lao, Xiang Qian.

In: International Journal of Hygiene and Environmental Health, Vol. 221, No. 1, 01.01.2018, p. 41-47.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Particulate matter air pollution, physical activity and systemic inflammation in Taiwanese adults

AU - Zhang, Zilong

AU - Hoek, Gerard

AU - Chang, Ly yun

AU - Chan, Ta Chien

AU - Guo, Cui

AU - Chuang, Yuan Chieh

AU - Chan, Jimmy

AU - Lin, Changqing

AU - Jiang, Wun Kai

AU - Guo, Yuming

AU - Vermeulen, Roel

AU - Yeoh, Eng kiong

AU - Tam, Tony

AU - Lau, Alexis K.H.

AU - Griffiths, Sian

AU - Lao, Xiang Qian

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background The protective effects of physical activity (PA) against chronic disease can be partially ascribed to its anti-inflammatory effects. On the other hand, long-term exposure to particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5) may induce systemic inflammation. Objective To investigate the joint effects of habitual PA and long-term exposure to PM2.5 on systemic inflammation in a large cohort of Taiwanese adults. Methods We studied 359,067 adult participants from a cohort consisting of Taiwanese residents who participated in a standard medical examination program from 2001 to 2014. Peripheral white blood cell (WBC) and differential counts were measured as indicators of systemic inflammation. Two-year average concentration of PM2.5 was estimated at each participant's address using a satellite-based spatio-temporal model. Habitual PA level was assessed by questionnaire (inactive, low, moderate and high). Mixed-effects linear regression model was used to examine the associations of WBC counts with PM2.5 and PA. Results Compared with inactive participants, those with low, moderate or high PA levels had 0.36% [95% confidence interval (CI): 0.31%, 0.41%], 0.70% (95%CI: 0.65%, 0.76%) and 1.16% (95%CI: 1.11%, 1.22%) lower WBC counts, respectively, after adjusting for PM2.5 exposure and a wide range of confounders. Long-term PM2.5 exposure was associated with increased WBC counts at all PA levels. Analyses for differential counts generated similar results. No significant interaction was observed between PA and PM2.5 exposure (P for interaction = 0.59). Conclusions Habitual PA was associated with statistically significant lower markers of systemic inflammation across different levels of PM2.5. Effects of PA and PM2.5 exposure on systemic inflammation are independent.

AB - Background The protective effects of physical activity (PA) against chronic disease can be partially ascribed to its anti-inflammatory effects. On the other hand, long-term exposure to particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5) may induce systemic inflammation. Objective To investigate the joint effects of habitual PA and long-term exposure to PM2.5 on systemic inflammation in a large cohort of Taiwanese adults. Methods We studied 359,067 adult participants from a cohort consisting of Taiwanese residents who participated in a standard medical examination program from 2001 to 2014. Peripheral white blood cell (WBC) and differential counts were measured as indicators of systemic inflammation. Two-year average concentration of PM2.5 was estimated at each participant's address using a satellite-based spatio-temporal model. Habitual PA level was assessed by questionnaire (inactive, low, moderate and high). Mixed-effects linear regression model was used to examine the associations of WBC counts with PM2.5 and PA. Results Compared with inactive participants, those with low, moderate or high PA levels had 0.36% [95% confidence interval (CI): 0.31%, 0.41%], 0.70% (95%CI: 0.65%, 0.76%) and 1.16% (95%CI: 1.11%, 1.22%) lower WBC counts, respectively, after adjusting for PM2.5 exposure and a wide range of confounders. Long-term PM2.5 exposure was associated with increased WBC counts at all PA levels. Analyses for differential counts generated similar results. No significant interaction was observed between PA and PM2.5 exposure (P for interaction = 0.59). Conclusions Habitual PA was associated with statistically significant lower markers of systemic inflammation across different levels of PM2.5. Effects of PA and PM2.5 exposure on systemic inflammation are independent.

KW - Particulate matter

KW - Physical activity

KW - Systemic inflammation

KW - White blood cell

UR - http://www.scopus.com/inward/record.url?scp=85030771787&partnerID=8YFLogxK

U2 - 10.1016/j.ijheh.2017.10.001

DO - 10.1016/j.ijheh.2017.10.001

M3 - Article

VL - 221

SP - 41

EP - 47

JO - International Journal of Hygiene and Environmental Health

JF - International Journal of Hygiene and Environmental Health

SN - 1438-4639

IS - 1

ER -