TY - JOUR
T1 - Particulate matter air pollution and blood glucose in children and adolescents
T2 - A cross-sectional study in China
AU - Zhang, Zilong
AU - Dong, Bin
AU - Li, Shanshan
AU - Chen, Gongbo
AU - Yang, Zhaogeng
AU - Dong, Yanhui
AU - Wang, Zhenghe
AU - Guo, Yuming
AU - Ma, Jun
PY - 2019/11/15
Y1 - 2019/11/15
N2 - Background: The health effects of particulate matter (PM) air pollution on glucose metabolism have been rarely examined in children and adolescents. Objective: We aimed to investigate the associations between long-term PM exposure and blood glucose and prevalence of impaired fasting glucose in a large population of Chinese children and adolescents. Methods: In 2013, a total of 11,814 children and adolescents aged 7 to 18 years were recruited from seven provinces/municipalities in China. Fasting blood sample was taken for the measurement of blood glucose. Satellite-based spatial-temporal models were used to estimate exposure to ambient submicrometer particles (PM1), fine particles (PM2.5) and thoracic particles (PM10). Cross-sectional analyses were performed using mixed-effects multivariable linear and logistic regression models. Results: After adjustment for a range of covariates, every 10 μg/m3 increment in PM1, PM2.5 and PM10 concentrations was associated with 0.160 [95% confidence interval (CI): 0.039, 0.280], 0.150 (95% CI: 0.044, 0.256) and 0.079 (95% CI: −0.009, 0.167) mmol/L higher blood glucose levels, respectively. PM exposure was also associated with higher prevalence of impaired fasting glucose, but the associations did not reach statistical significance [odds ratio per 10 μg/m3 increment in PM1, PM2.5 and PM10: 1.30 (95% CI: 0.86,1.96), 1.20 (95% CI: 0.85,1.69) and 1.08 (95% CI: 0.83,1.41)]. Conclusions: We found that long-term exposure to PM air pollution was associated with increased levels of blood glucose in children and adolescents. The associations were more evident for PM1 and PM2.5.
AB - Background: The health effects of particulate matter (PM) air pollution on glucose metabolism have been rarely examined in children and adolescents. Objective: We aimed to investigate the associations between long-term PM exposure and blood glucose and prevalence of impaired fasting glucose in a large population of Chinese children and adolescents. Methods: In 2013, a total of 11,814 children and adolescents aged 7 to 18 years were recruited from seven provinces/municipalities in China. Fasting blood sample was taken for the measurement of blood glucose. Satellite-based spatial-temporal models were used to estimate exposure to ambient submicrometer particles (PM1), fine particles (PM2.5) and thoracic particles (PM10). Cross-sectional analyses were performed using mixed-effects multivariable linear and logistic regression models. Results: After adjustment for a range of covariates, every 10 μg/m3 increment in PM1, PM2.5 and PM10 concentrations was associated with 0.160 [95% confidence interval (CI): 0.039, 0.280], 0.150 (95% CI: 0.044, 0.256) and 0.079 (95% CI: −0.009, 0.167) mmol/L higher blood glucose levels, respectively. PM exposure was also associated with higher prevalence of impaired fasting glucose, but the associations did not reach statistical significance [odds ratio per 10 μg/m3 increment in PM1, PM2.5 and PM10: 1.30 (95% CI: 0.86,1.96), 1.20 (95% CI: 0.85,1.69) and 1.08 (95% CI: 0.83,1.41)]. Conclusions: We found that long-term exposure to PM air pollution was associated with increased levels of blood glucose in children and adolescents. The associations were more evident for PM1 and PM2.5.
KW - Adolescents
KW - Blood glucose
KW - Children
KW - Particulate matter
UR - http://www.scopus.com/inward/record.url?scp=85069514857&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2019.07.179
DO - 10.1016/j.scitotenv.2019.07.179
M3 - Article
C2 - 31326810
AN - SCOPUS:85069514857
VL - 691
SP - 868
EP - 873
JO - Science of the Total Environment
JF - Science of the Total Environment
SN - 0048-9697
ER -
