TY - JOUR
T1 - Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla
AU - Boerboom, Derek
AU - Lafond, Jean-Francois
AU - Zheng, Xiaofeng
AU - Lapointe, Evelyne
AU - Mittaz, Laureane
AU - Boyer, Alexandre
AU - Pritchard, Melanie
AU - Demayo, Francesco
AU - Mort, John
AU - Drolet, Richard
AU - Richards, JoAnne
PY - 2011
Y1 - 2011
N2 - Adamts4 encodes a widely-expressed proteinase thought to be involved in processes ranging from cartilage metabolism to ovarian follicle development. To study its physiological roles, Adamts4-null mice were created by gene targeting. Unexpectedly, these were found to be phenotypically normal, suggesting that other gene(s) may compensate for its loss. Adamts4(-/-) mice were, therefore, crossed with a strain lacking Adamts1, whose pattern of expression and substrate specificity overlap that of Adamts4. Most (>95 ) Adamts1(-/-) ;Adamts4(-/-) mice died within 72 hr after birth with a marked thinning of the renal medulla. The renal defect was not observed in embryonic Adamts1(-/-) ;Adamts4(-/-) kidneys, but became apparent around birth. The few (
AB - Adamts4 encodes a widely-expressed proteinase thought to be involved in processes ranging from cartilage metabolism to ovarian follicle development. To study its physiological roles, Adamts4-null mice were created by gene targeting. Unexpectedly, these were found to be phenotypically normal, suggesting that other gene(s) may compensate for its loss. Adamts4(-/-) mice were, therefore, crossed with a strain lacking Adamts1, whose pattern of expression and substrate specificity overlap that of Adamts4. Most (>95 ) Adamts1(-/-) ;Adamts4(-/-) mice died within 72 hr after birth with a marked thinning of the renal medulla. The renal defect was not observed in embryonic Adamts1(-/-) ;Adamts4(-/-) kidneys, but became apparent around birth. The few (
UR - http://onlinelibrary.wiley.com/doi/10.1002/dvdy.22662/pdf
U2 - 10.1002/dvdy.22662
DO - 10.1002/dvdy.22662
M3 - Article
SN - 1058-8388
VL - 240
SP - 1806
EP - 1814
JO - Developmental Dynamics
JF - Developmental Dynamics
IS - 7
ER -