Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla

Derek Boerboom, Jean-Francois Lafond, Xiaofeng Zheng, Evelyne Lapointe, Laureane Mittaz, Alexandre Boyer, Melanie Pritchard, Francesco Demayo, John Mort, Richard Drolet, JoAnne Richards

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17 Citations (Scopus)


Adamts4 encodes a widely-expressed proteinase thought to be involved in processes ranging from cartilage metabolism to ovarian follicle development. To study its physiological roles, Adamts4-null mice were created by gene targeting. Unexpectedly, these were found to be phenotypically normal, suggesting that other gene(s) may compensate for its loss. Adamts4(-/-) mice were, therefore, crossed with a strain lacking Adamts1, whose pattern of expression and substrate specificity overlap that of Adamts4. Most (>95 ) Adamts1(-/-) ;Adamts4(-/-) mice died within 72 hr after birth with a marked thinning of the renal medulla. The renal defect was not observed in embryonic Adamts1(-/-) ;Adamts4(-/-) kidneys, but became apparent around birth. The few (
Original languageEnglish
Pages (from-to)1806 - 1814
Number of pages9
JournalDevelopmental Dynamics
Issue number7
Publication statusPublished - 2011

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