Partial purification and antinociceptive investigation of extracts of leaves of Labisia Pumila

Loshnie Samuagam, Gabriel Akyirem Akowuah, Patrick N. Okechukwu

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3 Citations (Scopus)


Labisia pumila, LP (Myrsinaceae), is a popular herb among the women in Malaysia known locally as "Kacip Fatimah". It has been used by many generations of Malay women to induce and facilitate child birth as well as a post partum medicine. This study was aimed to investigate the partially purified crude extracts of DCM from the leaves of LP for its antinociceptive and analgesic effects against two noxious stimuli; thermal (hot plate) and chemical (formalin). Partial purification of crude DCM extract resulted in 5 different fractions (A-E). All the fraction of crude DCM extract of LP showed significant antinociceptive and analgesic activity in both the hot plate test and formalin test. Phytochemical test showed the presence of flavanoids, tannins, saponins, alkaloids and steroids which have contributed to the results obtained in the hot plate and formalin study. Based on the results, LP seem to exhibit a central and peripheral analgesic properties and further studies are necessary to elucidate the mechanism of its traditional effects and its potential to treatment of pain.

Original languageEnglish
Pages (from-to)44-46
Number of pages3
JournalAsian Journal of Pharmaceutical and Clinical Research
Issue number4
Publication statusPublished - Oct 2011
Externally publishedYes


  • Antinocieptive
  • Formalin
  • Hot plate
  • Labisia pumila
  • Phytochemical

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