Partial amniotic carbon dioxide insufflation for fetal surgery

Sasha Skinner, Philip DeKoninck, Kelly Crossley, Benjamin Amberg, Jan Deprest, Stuart Hooper, Ryan Hodges

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)


Partial amniotic carbon dioxide insufflation (PACI) involves insufflating the amniotic sac with carbon dioxide (CO2) and, in some cases, draining some of the amniotic fluid. The creation of a gaseous intra-amniotic compartment improves visualization, even in the presence of limited bleeding, and creates the work space required for complex fetoscopic procedures. Clinically, PACI is mostly used to perform fetoscopic myelomeningocele (MMC) repair, enabling a minimally invasive alternative to open fetal surgery. However, evidence of the fetal safety of PACI is limited. Previous animal experiments in sheep demonstrate that PACI induces fetal hypercapnia and acidosis with largely unknown short and longer term implications. In this review, we examine the literature for the physiological effects of intrauterine insufflation pressure, duration, humidity, and the role of maternal hyperventilation on fetal physiology and well-being.

Original languageEnglish
Pages (from-to)983-993
Number of pages11
JournalPrenatal Diagnosis
Issue number13
Publication statusPublished - Dec 2018

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