@article{4c7e83912aa34b5b939efd8c69869b89,
title = "Parkinson{\textquoteright}s disease iron deposition caused by nitric oxide- induced loss of β-amyloid precursor protein",
abstract = "Elevation of both neuronal iron and nitric oxide (NO) in the substantia nigra are associated with Parkinson{\textquoteright}s disease (PD) pathogenesis. We reported previously that the Alzheimer-associated β-amyloid precursor protein (APP) facilitates neuronal iron export. Here we report markedly decreased APP expression in dopaminergic neurons of human PD nigra and that APP−/−mice develop iron-dependent nigral cell loss. Conversely, APP-overexpressing mice are protected in the MPTP PD model. NO suppresses APP translation in mouse MPTP models, explaining how elevated NO causes iron-dependent neurodegeneration in PD.",
keywords = "APP, Iron, Nitric oxide",
author = "Scott Ayton and Peng Lei and Hare, {Dominic J.} and Duce, {James A.} and George, {Jessica L.} and Adlard, {Paul A.} and Catriona McLean and Rogers, {Jack T.} and Cherny, {Robert A.} and Finkelstein, {David I.} and Bush, {Ashley I.}",
note = "Funding Information: This work was supported by funds from the Australian Research Council, the Australian National Health and MedicalResearchCouncil,theBethlehemGriffithsResearchFoundation,andtheOperationalInfrastructureSupport fromtheVictorianStateGovernment.TheVictorianBrainBankNetworkissupportedbytheUniversityofMelbourne, the Florey Institute of Neuroscience and Mental Health, the Alfred Hospital, and the Victorian Forensic Institute of Medicine. *D.I.F. and A.I.B. contributed equally to this work. Funding Information: This work was supported by funds from the Australian Research Council, the Australian National Health and Medical Research Council, the Bethlehem Griffiths Research Foundation, and the Operational Infrastructure Support from the Victorian State Government. The Victorian Brain Bank Network is supported by the University of Melbourne, the Florey Institute of Neuroscience and Mental Health, the Alfred Hospital, and the Victorian Forensic Institute of Medicine. Publisher Copyright: {\textcopyright} 2015 the authors.",
year = "2015",
month = feb,
day = "25",
doi = "10.1523/JNEUROSCI.3439-14.2015",
language = "English",
volume = "35",
pages = "3591--3597",
journal = "The Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "8",
}
