Abstract
Patients with Parkinson disease (PD) experience hyperalgesia on evoked pain sensitivity testing, although the relationship of this with persistent pain in PD is less certain. Studies examining this have generated contradictory findings. Further, the role of dopaminergic deficiency as an underlying substrate for hyperalgesia is controversial. We report the results of meta-analyses of the PD pain sensitivity literature in an attempt to answer these questions. We identified 429 records, of which ten articles compared pain sensitivity between PD patients that experienced clinical pain (PDP) to those who did not (PDNP), and twenty studies that examined the effect of dopaminergic medications on pain sensitivity in PD patients. PDP patients experienced a moderate increase in pain sensitivity, had more severe disease, required higher dosages of medication, and were more likely to be female when compared to those PDNP patients. PD patients also had reduced pain sensitivity when tested on dopaminergic medications compared to when they were not on medications. Overall, the results of this systematic review and meta-analysis supports the hypothesis that hyperalgesia contributes to clinical pain in PD, and that the underlying mechanism may be dopaminergically driven.
| Original language | English |
|---|---|
| Pages (from-to) | 172-206 |
| Number of pages | 35 |
| Journal | Journal of the Neurological Sciences |
| Volume | 395 |
| DOIs | |
| Publication status | Published - 15 Dec 2018 |
Cite this
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Parkinson disease : A systemic review of pain sensitivities and its association with clinical pain and response to dopaminergic stimulation. / Sung, Simon; Vijiaratnam, Nirosen; Chan, Daniela Wan Chi; Farrell, Michael; Evans, Andrew H.
In: Journal of the Neurological Sciences, Vol. 395, 15.12.2018, p. 172-206.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Parkinson disease
T2 - A systemic review of pain sensitivities and its association with clinical pain and response to dopaminergic stimulation
AU - Sung, Simon
AU - Vijiaratnam, Nirosen
AU - Chan, Daniela Wan Chi
AU - Farrell, Michael
AU - Evans, Andrew H.
PY - 2018/12/15
Y1 - 2018/12/15
N2 - Patients with Parkinson disease (PD) experience hyperalgesia on evoked pain sensitivity testing, although the relationship of this with persistent pain in PD is less certain. Studies examining this have generated contradictory findings. Further, the role of dopaminergic deficiency as an underlying substrate for hyperalgesia is controversial. We report the results of meta-analyses of the PD pain sensitivity literature in an attempt to answer these questions. We identified 429 records, of which ten articles compared pain sensitivity between PD patients that experienced clinical pain (PDP) to those who did not (PDNP), and twenty studies that examined the effect of dopaminergic medications on pain sensitivity in PD patients. PDP patients experienced a moderate increase in pain sensitivity, had more severe disease, required higher dosages of medication, and were more likely to be female when compared to those PDNP patients. PD patients also had reduced pain sensitivity when tested on dopaminergic medications compared to when they were not on medications. Overall, the results of this systematic review and meta-analysis supports the hypothesis that hyperalgesia contributes to clinical pain in PD, and that the underlying mechanism may be dopaminergically driven.
AB - Patients with Parkinson disease (PD) experience hyperalgesia on evoked pain sensitivity testing, although the relationship of this with persistent pain in PD is less certain. Studies examining this have generated contradictory findings. Further, the role of dopaminergic deficiency as an underlying substrate for hyperalgesia is controversial. We report the results of meta-analyses of the PD pain sensitivity literature in an attempt to answer these questions. We identified 429 records, of which ten articles compared pain sensitivity between PD patients that experienced clinical pain (PDP) to those who did not (PDNP), and twenty studies that examined the effect of dopaminergic medications on pain sensitivity in PD patients. PDP patients experienced a moderate increase in pain sensitivity, had more severe disease, required higher dosages of medication, and were more likely to be female when compared to those PDNP patients. PD patients also had reduced pain sensitivity when tested on dopaminergic medications compared to when they were not on medications. Overall, the results of this systematic review and meta-analysis supports the hypothesis that hyperalgesia contributes to clinical pain in PD, and that the underlying mechanism may be dopaminergically driven.
UR - http://www.scopus.com/inward/record.url?scp=85055487580&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2018.10.013
DO - 10.1016/j.jns.2018.10.013
M3 - Review Article
VL - 395
SP - 172
EP - 206
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
ER -