Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program

Richard J Anney, Ziarih Hawi, Karen Sheehan, Aisling Mulligan, Carlos Miguel Pinto, Keeley Joanne Brookes, Xaiohui Xu, Kaixin Zhou, Barbara Franke, Jan K Buitelaar, Sita H H M Vermeulen, Tobias Banaschewski, Edmund J S Sonuga-Barke, Richard P Ebstein, Iris Manor, Ana Lucia Miranda, Fernando Mulas, Robert D Oades, Herbert Roeyers, Nanda N J RommelseAribert Rothenberger, Joseph A Sergeant, Hans Christoph Steinhausen, Eric T Taylor, Margaret Jane J Thompson, Philip J Asherson, Stephen V Faraone, Michael Gill

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There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (?1 2 = 1:82, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P <0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD
Original languageEnglish
Pages (from-to)1495 - 1500
Number of pages6
JournalAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Issue number8
Publication statusPublished - 2008
Externally publishedYes

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