Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program

Richard J Anney, Ziarih Hawi, Karen Sheehan, Aisling Mulligan, Carlos Miguel Pinto, Keeley Joanne Brookes, Xaiohui Xu, Kaixin Zhou, Barbara Franke, Jan K Buitelaar, Sita H H M Vermeulen, Tobias Banaschewski, Edmund J S Sonuga-Barke, Richard P Ebstein, Iris Manor, Ana Lucia Miranda, Fernando Mulas, Robert D Oades, Herbert Roeyers, Nanda N J Rommelse & 8 others Aribert Rothenberger, Joseph A Sergeant, Hans Christoph Steinhausen, Eric T Taylor, Margaret Jane J Thompson, Philip J Asherson, Stephen V Faraone, Michael Gill

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22 Citations (Scopus)

Abstract

There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (?1 2 = 1:82, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P <0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD
Original languageEnglish
Pages (from-to)1495 - 1500
Number of pages6
JournalAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume147
Issue number8
DOIs
Publication statusPublished - 2008
Externally publishedYes

Cite this

Anney, Richard J ; Hawi, Ziarih ; Sheehan, Karen ; Mulligan, Aisling ; Pinto, Carlos Miguel ; Brookes, Keeley Joanne ; Xu, Xaiohui ; Zhou, Kaixin ; Franke, Barbara ; Buitelaar, Jan K ; Vermeulen, Sita H H M ; Banaschewski, Tobias ; Sonuga-Barke, Edmund J S ; Ebstein, Richard P ; Manor, Iris ; Miranda, Ana Lucia ; Mulas, Fernando ; Oades, Robert D ; Roeyers, Herbert ; Rommelse, Nanda N J ; Rothenberger, Aribert ; Sergeant, Joseph A ; Steinhausen, Hans Christoph ; Taylor, Eric T ; Thompson, Margaret Jane J ; Asherson, Philip J ; Faraone, Stephen V ; Gill, Michael. / Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program. In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2008 ; Vol. 147, No. 8. pp. 1495 - 1500.
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title = "Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program",
abstract = "There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (?1 2 = 1:82, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P <0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD",
author = "Anney, {Richard J} and Ziarih Hawi and Karen Sheehan and Aisling Mulligan and Pinto, {Carlos Miguel} and Brookes, {Keeley Joanne} and Xaiohui Xu and Kaixin Zhou and Barbara Franke and Buitelaar, {Jan K} and Vermeulen, {Sita H H M} and Tobias Banaschewski and Sonuga-Barke, {Edmund J S} and Ebstein, {Richard P} and Iris Manor and Miranda, {Ana Lucia} and Fernando Mulas and Oades, {Robert D} and Herbert Roeyers and Rommelse, {Nanda N J} and Aribert Rothenberger and Sergeant, {Joseph A} and Steinhausen, {Hans Christoph} and Taylor, {Eric T} and Thompson, {Margaret Jane J} and Asherson, {Philip J} and Faraone, {Stephen V} and Michael Gill",
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Anney, RJ, Hawi, Z, Sheehan, K, Mulligan, A, Pinto, CM, Brookes, KJ, Xu, X, Zhou, K, Franke, B, Buitelaar, JK, Vermeulen, SHHM, Banaschewski, T, Sonuga-Barke, EJS, Ebstein, RP, Manor, I, Miranda, AL, Mulas, F, Oades, RD, Roeyers, H, Rommelse, NNJ, Rothenberger, A, Sergeant, JA, Steinhausen, HC, Taylor, ET, Thompson, MJJ, Asherson, PJ, Faraone, SV & Gill, M 2008, 'Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 147, no. 8, pp. 1495 - 1500. https://doi.org/10.1002/ajmg.b.30659

Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program. / Anney, Richard J; Hawi, Ziarih ; Sheehan, Karen; Mulligan, Aisling; Pinto, Carlos Miguel; Brookes, Keeley Joanne; Xu, Xaiohui; Zhou, Kaixin; Franke, Barbara; Buitelaar, Jan K; Vermeulen, Sita H H M; Banaschewski, Tobias; Sonuga-Barke, Edmund J S; Ebstein, Richard P; Manor, Iris; Miranda, Ana Lucia; Mulas, Fernando; Oades, Robert D; Roeyers, Herbert; Rommelse, Nanda N J; Rothenberger, Aribert; Sergeant, Joseph A; Steinhausen, Hans Christoph; Taylor, Eric T; Thompson, Margaret Jane J; Asherson, Philip J; Faraone, Stephen V; Gill, Michael.

In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 147, No. 8, 2008, p. 1495 - 1500.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program

AU - Anney, Richard J

AU - Hawi, Ziarih

AU - Sheehan, Karen

AU - Mulligan, Aisling

AU - Pinto, Carlos Miguel

AU - Brookes, Keeley Joanne

AU - Xu, Xaiohui

AU - Zhou, Kaixin

AU - Franke, Barbara

AU - Buitelaar, Jan K

AU - Vermeulen, Sita H H M

AU - Banaschewski, Tobias

AU - Sonuga-Barke, Edmund J S

AU - Ebstein, Richard P

AU - Manor, Iris

AU - Miranda, Ana Lucia

AU - Mulas, Fernando

AU - Oades, Robert D

AU - Roeyers, Herbert

AU - Rommelse, Nanda N J

AU - Rothenberger, Aribert

AU - Sergeant, Joseph A

AU - Steinhausen, Hans Christoph

AU - Taylor, Eric T

AU - Thompson, Margaret Jane J

AU - Asherson, Philip J

AU - Faraone, Stephen V

AU - Gill, Michael

PY - 2008

Y1 - 2008

N2 - There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (?1 2 = 1:82, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P <0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD

AB - There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (?1 2 = 1:82, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P <0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD

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DO - 10.1002/ajmg.b.30659

M3 - Article

VL - 147

SP - 1495

EP - 1500

JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 8

ER -