parC Variants in Mycoplasma genitalium: Trends over Time and Association with Moxifloxacin Failure

Gerald L. Murray; Kaveesha Bodiyabadu; Lenka A. Vodstrcil; Dorothy A. Machalek; Jennifer Danielewski; Erica L. Plummer; Suzanne M. Garland; David M. Whiley; Emma L. Sweeney; Catriona S. Bradshaw

doi:10.1128/aac.00278-22

parC Variants in Mycoplasma genitalium: Trends over Time and Association with Moxifloxacin Failure

Gerald L. Murray, Kaveesha Bodiyabadu, Lenka A. Vodstrcil, Dorothy A. Machalek, Jennifer Danielewski, Erica L. Plummer, Suzanne M. Garland, David M. Whiley, Emma L. Sweeney, Catriona S. Bradshaw

Research output: Contribution to journal › Article › Research › peer-review

38 Citations (Scopus)

Abstract

Prevalence, trends, and treatment outcome estimates were generated for parC variants in macrolide-resistant Mycoplasma genitalium. Among 539 cases, the most common amino acid change was S83I, which increased from 13% in 2012 to 2013, to 23% in 2019 to 2020 (Ptrend = 0.046). From 381 moxifloxacin treatments, failure occurred in 58.7% (95% confidence interval [CI], 46.7 to 69.9) of cases with S83I. Other changes affecting S83 or D87 were uncommon and minor contributors to failure. The absence of S83I was highly predictive of moxifloxacin cure (96.4%; 95% CI, 93.7 to 98.2), highlighting diagnostic potential.

Original language	English
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	66
Issue number	5
DOIs	https://doi.org/10.1128/aac.00278-22
Publication status	Published - May 2022

Keywords

antibiotic resistance
fluoroquinolone
moxifloxacin
Mycoplasma genitalium
parC

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/aac.00278-22

Cite this

@article{64de1434397f41f68a679737a25dfd94,

title = "parC Variants in Mycoplasma genitalium: Trends over Time and Association with Moxifloxacin Failure",

abstract = "Prevalence, trends, and treatment outcome estimates were generated for parC variants in macrolide-resistant Mycoplasma genitalium. Among 539 cases, the most common amino acid change was S83I, which increased from 13\% in 2012 to 2013, to 23\% in 2019 to 2020 (Ptrend = 0.046). From 381 moxifloxacin treatments, failure occurred in 58.7\% (95\% confidence interval [CI], 46.7 to 69.9) of cases with S83I. Other changes affecting S83 or D87 were uncommon and minor contributors to failure. The absence of S83I was highly predictive of moxifloxacin cure (96.4\%; 95\% CI, 93.7 to 98.2), highlighting diagnostic potential. ",

keywords = "antibiotic resistance, fluoroquinolone, moxifloxacin, Mycoplasma genitalium, parC",

author = "Murray, \{Gerald L.\} and Kaveesha Bodiyabadu and Vodstrcil, \{Lenka A.\} and Machalek, \{Dorothy A.\} and Jennifer Danielewski and Plummer, \{Erica L.\} and Garland, \{Suzanne M.\} and Whiley, \{David M.\} and Sweeney, \{Emma L.\} and Bradshaw, \{Catriona S.\}",

note = "Funding Information: This work is supported by the Australian Research Council Research Hub to Combat Antimicrobial Resistance (project ID IH190100021 to G.L.M., C.S.B., and D.M.W.) and National Health and Medical Research Council Investigator Grant APP1197951 (to S.M.G.). Publisher Copyright: {\textcopyright} 2022 American Society for Microbiology.",

year = "2022",

month = may,

doi = "10.1128/aac.00278-22",

language = "English",

volume = "66",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "5",

}

TY - JOUR

T1 - parC Variants in Mycoplasma genitalium

T2 - Trends over Time and Association with Moxifloxacin Failure

AU - Murray, Gerald L.

AU - Bodiyabadu, Kaveesha

AU - Vodstrcil, Lenka A.

AU - Machalek, Dorothy A.

AU - Danielewski, Jennifer

AU - Plummer, Erica L.

AU - Garland, Suzanne M.

AU - Whiley, David M.

AU - Sweeney, Emma L.

AU - Bradshaw, Catriona S.

N1 - Funding Information: This work is supported by the Australian Research Council Research Hub to Combat Antimicrobial Resistance (project ID IH190100021 to G.L.M., C.S.B., and D.M.W.) and National Health and Medical Research Council Investigator Grant APP1197951 (to S.M.G.). Publisher Copyright: © 2022 American Society for Microbiology.

PY - 2022/5

Y1 - 2022/5

N2 - Prevalence, trends, and treatment outcome estimates were generated for parC variants in macrolide-resistant Mycoplasma genitalium. Among 539 cases, the most common amino acid change was S83I, which increased from 13% in 2012 to 2013, to 23% in 2019 to 2020 (Ptrend = 0.046). From 381 moxifloxacin treatments, failure occurred in 58.7% (95% confidence interval [CI], 46.7 to 69.9) of cases with S83I. Other changes affecting S83 or D87 were uncommon and minor contributors to failure. The absence of S83I was highly predictive of moxifloxacin cure (96.4%; 95% CI, 93.7 to 98.2), highlighting diagnostic potential.

AB - Prevalence, trends, and treatment outcome estimates were generated for parC variants in macrolide-resistant Mycoplasma genitalium. Among 539 cases, the most common amino acid change was S83I, which increased from 13% in 2012 to 2013, to 23% in 2019 to 2020 (Ptrend = 0.046). From 381 moxifloxacin treatments, failure occurred in 58.7% (95% confidence interval [CI], 46.7 to 69.9) of cases with S83I. Other changes affecting S83 or D87 were uncommon and minor contributors to failure. The absence of S83I was highly predictive of moxifloxacin cure (96.4%; 95% CI, 93.7 to 98.2), highlighting diagnostic potential.

KW - antibiotic resistance

KW - fluoroquinolone

KW - moxifloxacin

KW - Mycoplasma genitalium

KW - parC

UR - https://www.scopus.com/pages/publications/85130472956

U2 - 10.1128/aac.00278-22

DO - 10.1128/aac.00278-22

M3 - Article

C2 - 35475636

AN - SCOPUS:85130472956

SN - 0066-4804

VL - 66

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

parC Variants in Mycoplasma genitalium: Trends over Time and Association with Moxifloxacin Failure

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

ARC Research Hub to Combat Antimicrobial Resistance

Cite this

parC Variants in Mycoplasma genitalium: Trends over Time and Association with Moxifloxacin Failure

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

ARC Research Hub to Combat Antimicrobial Resistance

Cite this