Parasitic infection of the mucosal surfaces

Colby Zaph, David Artis

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

The mucosal surfaces of the body serve as the entry point for a wide variety of protozoan and helminthic parasites. Parasitic protozoa and helminths are eukaryotic organisms that survive intracellularly or in close contact with the mammalian host. Most parasitic infections of the mucosal surfaces are acquired orally through contact with contaminated food and water. However, some helminth parasites invade through the skin, migrating via the lung to the intestine. A wide variety of nonimmune and immune mechanisms have been described that mediate the recognition and control of parasites of mucosal tissues. In this chapter, we examine the distinct immunological pathways that are activated in response to a prototypic protozoan or helminthic parasite infection at mucosal surfaces.
Original languageEnglish
Title of host publicationMucosal Immunology
EditorsJiri Mestecky, Warren Strober, Michael W. Russell, Brian L. Kelsall, Hilde Cheroutre, Bart N. Lambrecht
Place of PublicationOxford UK
PublisherAcademic Press
Chapter54
Pages1023-1035
Number of pages13
Volume1
Edition4th
ISBN (Electronic)9780124159754
ISBN (Print)9780123972033
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Helminth parasite
  • Intestine
  • Mucosal immunity
  • Murine models
  • Protozoan parasite
  • Toxoplasma gondii
  • Trichuris muris

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