Parallel and antiparallel cyclic d/l peptide nanotubes

Mitchell R. Silk; Janet Newman; Julian C. Ratcliffe; Jacinta F White; Tom Caradoc-Davies; Jason R. Price; Sébastien Perrier; Philip E. Thompson; David K. Chalmers

doi:10.1039/c7cc00846e

Parallel and antiparallel cyclic d/l peptide nanotubes

Mitchell R. Silk, Janet Newman, Julian C. Ratcliffe, Jacinta F White, Tom Caradoc-Davies, Jason R. Price, Sébastien Perrier, Philip E. Thompson, David K. Chalmers

Research output: Contribution to journal › Article › Research › peer-review

36 Citations (Scopus)

Abstract

Nanotubes made from H-bonded cyclic d/l peptide (CP) subunits have great potential for the construction of nanomaterials of wide chemical and structural diversity but, to date, difficulties in structural characterisation have restricted development of these materials. We present the first crystal structures of continuous CP nanotubes with antiparallel and parallel stacking arrangements, assembled separately from two peptides; cyclo[(Asp-d-Leu-Lys-d-Leu)₂] and cyclo[(Asp-d-Ala-Lys-d-Ala)₂].

Original language	English
Pages (from-to)	6613-6616
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	49
DOIs	https://doi.org/10.1039/c7cc00846e
Publication status	Published - 2017

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10.1039/c7cc00846e

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T1 - Parallel and antiparallel cyclic d/l peptide nanotubes

AU - Silk, Mitchell R.

AU - Newman, Janet

AU - Ratcliffe, Julian C.

AU - White, Jacinta F

AU - Caradoc-Davies, Tom

AU - Price, Jason R.

AU - Perrier, Sébastien

AU - Thompson, Philip E.

AU - Chalmers, David K.

PY - 2017

Y1 - 2017

N2 - Nanotubes made from H-bonded cyclic d/l peptide (CP) subunits have great potential for the construction of nanomaterials of wide chemical and structural diversity but, to date, difficulties in structural characterisation have restricted development of these materials. We present the first crystal structures of continuous CP nanotubes with antiparallel and parallel stacking arrangements, assembled separately from two peptides; cyclo[(Asp-d-Leu-Lys-d-Leu)2] and cyclo[(Asp-d-Ala-Lys-d-Ala)2].

AB - Nanotubes made from H-bonded cyclic d/l peptide (CP) subunits have great potential for the construction of nanomaterials of wide chemical and structural diversity but, to date, difficulties in structural characterisation have restricted development of these materials. We present the first crystal structures of continuous CP nanotubes with antiparallel and parallel stacking arrangements, assembled separately from two peptides; cyclo[(Asp-d-Leu-Lys-d-Leu)2] and cyclo[(Asp-d-Ala-Lys-d-Ala)2].

UR - http://www.scopus.com/inward/record.url?scp=85021709045&partnerID=8YFLogxK

U2 - 10.1039/c7cc00846e

DO - 10.1039/c7cc00846e

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VL - 53

SP - 6613

EP - 6616

JO - Chemical Communications

JF - Chemical Communications

IS - 49

ER -

Parallel and antiparallel cyclic d/l peptide nanotubes

Abstract

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