Abstract
We investigated the relationship between telomerase activity and the expression of human telomerase reverse transcriptase (hTERT) and prostate apoptosis response 4 (Par-4) proteins in laryngocarcinoma cells. Following treatment with short hairpin RNA (shRNA) against hTERT, hTERT protein expression was inhibited, while Par-4 expression was increased. These changes were statistically significant (p<0.05), with Par-4 and hTERT expression being negatively correlated (p<0.05, r=-0.908). However, we found no correlation between telomerase activity and hTERT expression. Our findings suggest that hTERT exerts its anti-apoptotic effects through a telomerase-independent pathway, which is likely to intersect with the Par-4 apoptosis pathway.
Original language | English |
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Pages (from-to) | 365-369 |
Number of pages | 5 |
Journal | Tissue and Cell |
Volume | 42 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2010 |
Externally published | Yes |
Keywords
- Human telomerase reverse transcriptase
- Larygocarcinoma
- Prostate apoptosis response 4
- Short hairpin RNA