PAR-4 and hTERT expression are negatively correlated after RNA interference targeting hTERT in laryngocarcinoma cells

Jian Fei Sheng, Wei Chen, Yan Yu, Jun Liu, Ze-Zhang Tao

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4 Citations (Scopus)

Abstract

We investigated the relationship between telomerase activity and the expression of human telomerase reverse transcriptase (hTERT) and prostate apoptosis response 4 (Par-4) proteins in laryngocarcinoma cells. Following treatment with short hairpin RNA (shRNA) against hTERT, hTERT protein expression was inhibited, while Par-4 expression was increased. These changes were statistically significant (p<0.05), with Par-4 and hTERT expression being negatively correlated (p<0.05, r=-0.908). However, we found no correlation between telomerase activity and hTERT expression. Our findings suggest that hTERT exerts its anti-apoptotic effects through a telomerase-independent pathway, which is likely to intersect with the Par-4 apoptosis pathway.

Original languageEnglish
Pages (from-to)365-369
Number of pages5
JournalTissue and Cell
Volume42
Issue number6
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Keywords

  • Human telomerase reverse transcriptase
  • Larygocarcinoma
  • Prostate apoptosis response 4
  • Short hairpin RNA

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