PAR-4 and hTERT expression are negatively correlated after RNA interference targeting hTERT in laryngocarcinoma cells

Jian Fei Sheng; Wei Chen; Yan Yu; Jun Liu; Ze-Zhang Tao

doi:10.1016/j.tice.2010.08.002

PAR-4 and hTERT expression are negatively correlated after RNA interference targeting hTERT in laryngocarcinoma cells

Jian Fei Sheng, Wei Chen, Yan Yu, Jun Liu, Ze-Zhang Tao

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Abstract

We investigated the relationship between telomerase activity and the expression of human telomerase reverse transcriptase (hTERT) and prostate apoptosis response 4 (Par-4) proteins in laryngocarcinoma cells. Following treatment with short hairpin RNA (shRNA) against hTERT, hTERT protein expression was inhibited, while Par-4 expression was increased. These changes were statistically significant (p<0.05), with Par-4 and hTERT expression being negatively correlated (p<0.05, r=-0.908). However, we found no correlation between telomerase activity and hTERT expression. Our findings suggest that hTERT exerts its anti-apoptotic effects through a telomerase-independent pathway, which is likely to intersect with the Par-4 apoptosis pathway.

Original language	English
Pages (from-to)	365-369
Number of pages	5
Journal	Tissue and Cell
Volume	42
Issue number	6
DOIs	https://doi.org/10.1016/j.tice.2010.08.002
Publication status	Published - Dec 2010
Externally published	Yes

Keywords

Human telomerase reverse transcriptase
Larygocarcinoma
Prostate apoptosis response 4
Short hairpin RNA

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10.1016/j.tice.2010.08.002

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title = "PAR-4 and hTERT expression are negatively correlated after RNA interference targeting hTERT in laryngocarcinoma cells",

abstract = "We investigated the relationship between telomerase activity and the expression of human telomerase reverse transcriptase (hTERT) and prostate apoptosis response 4 (Par-4) proteins in laryngocarcinoma cells. Following treatment with short hairpin RNA (shRNA) against hTERT, hTERT protein expression was inhibited, while Par-4 expression was increased. These changes were statistically significant (p<0.05), with Par-4 and hTERT expression being negatively correlated (p<0.05, r=-0.908). However, we found no correlation between telomerase activity and hTERT expression. Our findings suggest that hTERT exerts its anti-apoptotic effects through a telomerase-independent pathway, which is likely to intersect with the Par-4 apoptosis pathway.",

keywords = "Human telomerase reverse transcriptase, Larygocarcinoma, Prostate apoptosis response 4, Short hairpin RNA",

author = "Sheng, {Jian Fei} and Wei Chen and Yan Yu and Jun Liu and Ze-Zhang Tao",

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doi = "10.1016/j.tice.2010.08.002",

language = "English",

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TY - JOUR

T1 - PAR-4 and hTERT expression are negatively correlated after RNA interference targeting hTERT in laryngocarcinoma cells

AU - Sheng, Jian Fei

AU - Chen, Wei

AU - Yu, Yan

AU - Liu, Jun

AU - Tao, Ze-Zhang

PY - 2010/12

Y1 - 2010/12

N2 - We investigated the relationship between telomerase activity and the expression of human telomerase reverse transcriptase (hTERT) and prostate apoptosis response 4 (Par-4) proteins in laryngocarcinoma cells. Following treatment with short hairpin RNA (shRNA) against hTERT, hTERT protein expression was inhibited, while Par-4 expression was increased. These changes were statistically significant (p<0.05), with Par-4 and hTERT expression being negatively correlated (p<0.05, r=-0.908). However, we found no correlation between telomerase activity and hTERT expression. Our findings suggest that hTERT exerts its anti-apoptotic effects through a telomerase-independent pathway, which is likely to intersect with the Par-4 apoptosis pathway.

AB - We investigated the relationship between telomerase activity and the expression of human telomerase reverse transcriptase (hTERT) and prostate apoptosis response 4 (Par-4) proteins in laryngocarcinoma cells. Following treatment with short hairpin RNA (shRNA) against hTERT, hTERT protein expression was inhibited, while Par-4 expression was increased. These changes were statistically significant (p<0.05), with Par-4 and hTERT expression being negatively correlated (p<0.05, r=-0.908). However, we found no correlation between telomerase activity and hTERT expression. Our findings suggest that hTERT exerts its anti-apoptotic effects through a telomerase-independent pathway, which is likely to intersect with the Par-4 apoptosis pathway.

KW - Human telomerase reverse transcriptase

KW - Larygocarcinoma

KW - Prostate apoptosis response 4

KW - Short hairpin RNA

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U2 - 10.1016/j.tice.2010.08.002

DO - 10.1016/j.tice.2010.08.002

M3 - Article

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AN - SCOPUS:78649886171

VL - 42

SP - 365

EP - 369

JO - Tissue and Cell

JF - Tissue and Cell

SN - 0040-8166

IS - 6

ER -

PAR-4 and hTERT expression are negatively correlated after RNA interference targeting hTERT in laryngocarcinoma cells

Abstract

Keywords

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