Palladium-Catalysed Carboborylation for the Synthesis of Borylated Indanes

Andrzej Zieba, Joel F. Hooper

Research output: Contribution to journalArticleOtherpeer-review

3 Citations (Scopus)

Abstract

A palladium-catalysed carboborylation reaction for the synthesis of borylated indanes has been investigated. This reaction proceeds in good yields with an achiral catalyst, and is tolerant of substitution on the aryl ring, although sensitivity to the substitution of the alkene was observed. Initial studies towards an enantioselective version of this reaction were undertaken, identifying phosphoramidites as a promising ligand class. This allowed for the synthesis of chiral indane and indolone products with moderate levels of enantioselectivity.

Original languageEnglish
Pages (from-to)4072-4075
Number of pages4
JournalEuropean Journal of Organic Chemistry
Volume2021
Issue number29
DOIs
Publication statusPublished - 6 Aug 2021

Keywords

  • Anion capture
  • Borylation
  • Cascade reactions
  • Cyclization
  • Homogeneous catalysis
  • Palladium

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