TY - JOUR
T1 - Palifermin, administered for three doses only, reduces mucositis in patients undergoing HSCT and receiving chemoradiotherapy conditioning
AU - Coutsouvelis, John
AU - Dooley, Michael
AU - Kirkpatrick, Carl M.
AU - Avery, Sharon
AU - Hopkins, Ria
AU - Spencer, Andrew
PY - 2022/8
Y1 - 2022/8
N2 - Oral mucositis, a common complication of chemotherapy and/or radiotherapy, presents with varying severity of erythematous and ulcerative lesions. Myeloablative chemotherapy and radiation-based conditioning with autologous and allogeneic haemopoietic stem cell transplantation (auHSCT, aHSCT) are established treatments for haematological malignancies. In these settings, the incidence of severe oral mucositis, defined as World Health Organization (WHO) grade 3 and 4 (G3/4), is reported at 80–100%, with a significant cost burden to health systems. It is described as a feared and incapacitating complication for patients, resulting in pain and difficulty eating, often requiring parenteral opioid analgesia (POA) and parenteral nutrition (PN).
AB - Oral mucositis, a common complication of chemotherapy and/or radiotherapy, presents with varying severity of erythematous and ulcerative lesions. Myeloablative chemotherapy and radiation-based conditioning with autologous and allogeneic haemopoietic stem cell transplantation (auHSCT, aHSCT) are established treatments for haematological malignancies. In these settings, the incidence of severe oral mucositis, defined as World Health Organization (WHO) grade 3 and 4 (G3/4), is reported at 80–100%, with a significant cost burden to health systems. It is described as a feared and incapacitating complication for patients, resulting in pain and difficulty eating, often requiring parenteral opioid analgesia (POA) and parenteral nutrition (PN).
UR - http://www.scopus.com/inward/record.url?scp=85130217268&partnerID=8YFLogxK
U2 - 10.1038/s41409-022-01714-6
DO - 10.1038/s41409-022-01714-6
M3 - Letter
AN - SCOPUS:85130217268
SN - 0268-3369
VL - 57
SP - 1329
EP - 1331
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 8
ER -