OBJECTIVE: To examine associations between late event-related cerebral potential amplitudes and behavioural responses to noxious electrical stimulation as an indicator of acute pain in sheep. DESIGN: Analysis of variance for the effects of stimulus intensity on the behaviour and event-related cerebral potential variables. PROCEDURE: Ninety-six brief constant current electrical pulse trains were presented to the front left leg of eight sheep at four intensities (2.5 to 10 mA) in a randomised order. An event-related cerebral potential and a graded flinch response were recorded for each stimulus and the 24 event-related cerebral potentials at each intensity were averaged to produce a mean waveform. Various components of this waveform were analysed and changes in these measures and the sheep's flinch response, as stimulus intensity increased, were determined. RESULTS: Both the flinch response and some event-related cerebral potential components, that is, peak amplitudes 114 [N1], 187 [P1], 318 [P2] and 230 [Pm] ms after stimulus onset, were significantly affected as stimulus intensity increased. CONCLUSION: These corresponding behavioural and event-related cerebral potential changes indicate the usefulness of using changes in the event-related cerebral potential to measure acute pain in sheep.
|Number of pages||4|
|Journal||Australian Veterinary Journal|
|Publication status||Published - 1 Jan 1997|