TY - JOUR
T1 - Pahangensin A and B, two new antibacterial diterpenes from the rhizomes of Alpinia pahangensis Ridley
AU - Sivasothy, Yasodha
AU - Ibrahim, Halijah
AU - Paliany, Audra Shaleena
AU - Alias, Siti Aisyah
AU - Awang, Khalijah
PY - 2013/12/1
Y1 - 2013/12/1
N2 - The rhizomes of Alpinia pahangensis Ridley yielded a new bis-labdanic diterpene for which the name pahangensin A (1) was proposed along with a new labdane diterpene, pahangensin B (2). Their structures were elucidated by spectroscopic methods including, 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Pahangensin A (1) was found to be an antibacterial agent against Staphylococcus aureus, Bacillus cereus and Bacillus subtilis with MIC values less than 100 μg/mL, respectively. Pahangensin B (2) exhibited antibacterial activity (MIC <100 μg/mL) against B. cereus.
AB - The rhizomes of Alpinia pahangensis Ridley yielded a new bis-labdanic diterpene for which the name pahangensin A (1) was proposed along with a new labdane diterpene, pahangensin B (2). Their structures were elucidated by spectroscopic methods including, 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Pahangensin A (1) was found to be an antibacterial agent against Staphylococcus aureus, Bacillus cereus and Bacillus subtilis with MIC values less than 100 μg/mL, respectively. Pahangensin B (2) exhibited antibacterial activity (MIC <100 μg/mL) against B. cereus.
KW - Alpinia pahangensis Ridley
KW - Antibacterial agent
KW - Bis-labdanic diterpene
KW - Labdane diterpene
KW - Pahangensin A
KW - Pahangensin B
KW - Zingiberaceae
UR - http://www.scopus.com/inward/record.url?scp=84886948887&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2013.09.082
DO - 10.1016/j.bmcl.2013.09.082
M3 - Article
C2 - 24144849
AN - SCOPUS:84886948887
SN - 0960-894X
VL - 23
SP - 6280
EP - 6285
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 23
ER -