Pahangensin A and B, two new antibacterial diterpenes from the rhizomes of Alpinia pahangensis Ridley

Yasodha Sivasothy, Halijah Ibrahim, Audra Shaleena Paliany, Siti Aisyah Alias, Khalijah Awang

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

The rhizomes of Alpinia pahangensis Ridley yielded a new bis-labdanic diterpene for which the name pahangensin A (1) was proposed along with a new labdane diterpene, pahangensin B (2). Their structures were elucidated by spectroscopic methods including, 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Pahangensin A (1) was found to be an antibacterial agent against Staphylococcus aureus, Bacillus cereus and Bacillus subtilis with MIC values less than 100 μg/mL, respectively. Pahangensin B (2) exhibited antibacterial activity (MIC <100 μg/mL) against B. cereus.

Original languageEnglish
Pages (from-to)6280-6285
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number23
DOIs
Publication statusPublished - 1 Dec 2013
Externally publishedYes

Keywords

  • Alpinia pahangensis Ridley
  • Antibacterial agent
  • Bis-labdanic diterpene
  • Labdane diterpene
  • Pahangensin A
  • Pahangensin B
  • Zingiberaceae

Cite this