Paediatric index of mortality 3: an updated model for predicting mortality in pediatric intensive care

Lahn David John Straney, Archie Campbell Adair Clements, Roger Parslow, Gale Pearson, Frank Shann, Janet Alexander, Anthony Slater

Research output: Contribution to journalArticleResearchpeer-review

91 Citations (Scopus)

Abstract

OBJECTIVES: To provide an updated version of the Paediatric Index of Mortality 2 for assessing the risk of mortality among children admitted to an ICU. DESIGN: International, multicenter, prospective cohort study. SETTING: Sixty ICUs that accept pediatric admissions in Australia, New Zealand, Ireland, and the United Kingdom. PATIENTS: All children admitted in 2010 and 2011 who were aged less than 16 years at the time of admission and either died in ICU or were discharged. Patients who were transferred to another ICU were not included. Fifty-three thousand one hundred twelve patient admissions were included in the analysis. INTERVENTIONS: None. MEASUREMENT AND MAIN RESULTS: A revised prediction model was built using logistic regression. Variable selection was based on significance at the 95 level and overall improvement of the model s discriminatory performance and goodness of fit. The final model discriminated well (area under the curve, 0.88, 0.88-0.89); however, the model performed better in Australia and New Zealand than in the United Kingdom and Ireland (area under the curve was 0.91, 0.90-0.93 and 0.85, 0.84-0.86, respectively). CONCLUSIONS: Paediatric Index of Mortality 3 provides an international standard based on a large contemporary dataset for the comparison of risk-adjusted mortality among children admitted to intensive care.
Original languageEnglish
Pages (from-to)673 - 681
Number of pages9
JournalPediatric Critical Care Medicine
Volume14
Issue number7
DOIs
Publication statusPublished - 2013

Cite this

Straney, Lahn David John ; Clements, Archie Campbell Adair ; Parslow, Roger ; Pearson, Gale ; Shann, Frank ; Alexander, Janet ; Slater, Anthony. / Paediatric index of mortality 3: an updated model for predicting mortality in pediatric intensive care. In: Pediatric Critical Care Medicine. 2013 ; Vol. 14, No. 7. pp. 673 - 681.
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abstract = "OBJECTIVES: To provide an updated version of the Paediatric Index of Mortality 2 for assessing the risk of mortality among children admitted to an ICU. DESIGN: International, multicenter, prospective cohort study. SETTING: Sixty ICUs that accept pediatric admissions in Australia, New Zealand, Ireland, and the United Kingdom. PATIENTS: All children admitted in 2010 and 2011 who were aged less than 16 years at the time of admission and either died in ICU or were discharged. Patients who were transferred to another ICU were not included. Fifty-three thousand one hundred twelve patient admissions were included in the analysis. INTERVENTIONS: None. MEASUREMENT AND MAIN RESULTS: A revised prediction model was built using logistic regression. Variable selection was based on significance at the 95 level and overall improvement of the model s discriminatory performance and goodness of fit. The final model discriminated well (area under the curve, 0.88, 0.88-0.89); however, the model performed better in Australia and New Zealand than in the United Kingdom and Ireland (area under the curve was 0.91, 0.90-0.93 and 0.85, 0.84-0.86, respectively). CONCLUSIONS: Paediatric Index of Mortality 3 provides an international standard based on a large contemporary dataset for the comparison of risk-adjusted mortality among children admitted to intensive care.",
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Paediatric index of mortality 3: an updated model for predicting mortality in pediatric intensive care. / Straney, Lahn David John; Clements, Archie Campbell Adair; Parslow, Roger; Pearson, Gale; Shann, Frank; Alexander, Janet; Slater, Anthony.

In: Pediatric Critical Care Medicine, Vol. 14, No. 7, 2013, p. 673 - 681.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Paediatric index of mortality 3: an updated model for predicting mortality in pediatric intensive care

AU - Straney, Lahn David John

AU - Clements, Archie Campbell Adair

AU - Parslow, Roger

AU - Pearson, Gale

AU - Shann, Frank

AU - Alexander, Janet

AU - Slater, Anthony

PY - 2013

Y1 - 2013

N2 - OBJECTIVES: To provide an updated version of the Paediatric Index of Mortality 2 for assessing the risk of mortality among children admitted to an ICU. DESIGN: International, multicenter, prospective cohort study. SETTING: Sixty ICUs that accept pediatric admissions in Australia, New Zealand, Ireland, and the United Kingdom. PATIENTS: All children admitted in 2010 and 2011 who were aged less than 16 years at the time of admission and either died in ICU or were discharged. Patients who were transferred to another ICU were not included. Fifty-three thousand one hundred twelve patient admissions were included in the analysis. INTERVENTIONS: None. MEASUREMENT AND MAIN RESULTS: A revised prediction model was built using logistic regression. Variable selection was based on significance at the 95 level and overall improvement of the model s discriminatory performance and goodness of fit. The final model discriminated well (area under the curve, 0.88, 0.88-0.89); however, the model performed better in Australia and New Zealand than in the United Kingdom and Ireland (area under the curve was 0.91, 0.90-0.93 and 0.85, 0.84-0.86, respectively). CONCLUSIONS: Paediatric Index of Mortality 3 provides an international standard based on a large contemporary dataset for the comparison of risk-adjusted mortality among children admitted to intensive care.

AB - OBJECTIVES: To provide an updated version of the Paediatric Index of Mortality 2 for assessing the risk of mortality among children admitted to an ICU. DESIGN: International, multicenter, prospective cohort study. SETTING: Sixty ICUs that accept pediatric admissions in Australia, New Zealand, Ireland, and the United Kingdom. PATIENTS: All children admitted in 2010 and 2011 who were aged less than 16 years at the time of admission and either died in ICU or were discharged. Patients who were transferred to another ICU were not included. Fifty-three thousand one hundred twelve patient admissions were included in the analysis. INTERVENTIONS: None. MEASUREMENT AND MAIN RESULTS: A revised prediction model was built using logistic regression. Variable selection was based on significance at the 95 level and overall improvement of the model s discriminatory performance and goodness of fit. The final model discriminated well (area under the curve, 0.88, 0.88-0.89); however, the model performed better in Australia and New Zealand than in the United Kingdom and Ireland (area under the curve was 0.91, 0.90-0.93 and 0.85, 0.84-0.86, respectively). CONCLUSIONS: Paediatric Index of Mortality 3 provides an international standard based on a large contemporary dataset for the comparison of risk-adjusted mortality among children admitted to intensive care.

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