Paediatric HIV infection: The potential for cure

Philip JR Goulder; Sharon R. Lewin; Ellen M. Leitman

doi:10.1038/nri.2016.19

Paediatric HIV infection: The potential for cure

Philip JR Goulder, Sharon R. Lewin, Ellen M. Leitman

Infectious Diseases

Research output: Contribution to journal › Review Article › Other › peer-review

94 Citations (Scopus)

Abstract

Recent anecdotal reports of HIV-infected children who received early antiretroviral therapy (ART) and showed sustained control of viral replication even after ART discontinuation have raised the question of whether there is greater intrinsic potential for HIV remission, or even eradication ('cure'), in paediatric infection than in adult infection. This Review describes the influence of early initiation of ART, of immune ontogeny and of maternal factors on the potential for HIV cure in children and discusses the unique immunotherapeutic opportunities and obstacles that paediatric infection may present.

Original language	English
Pages (from-to)	259-271
Number of pages	13
Journal	Nature Reviews Immunology
Volume	16
Issue number	4
DOIs	https://doi.org/10.1038/nri.2016.19
Publication status	Published - 30 Mar 2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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105998218-oaAccepted author manuscript, 1.04 MB

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Paediatric HIV infection: The potential for cure

Abstract

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