Paclitaxel and its evolving role in the management of ovarian cancer

Nirmala Chandralega Kampan; Mutsa Tatenda Madondo; Orla M McNally; Michael Quinn; Magdalena Plebanski

doi:10.1155/2015/413076

Paclitaxel and its evolving role in the management of ovarian cancer

Nirmala Chandralega Kampan, Mutsa Tatenda Madondo, Orla M McNally, Michael Quinn, Magdalena Plebanski

Immunology Alfred Hospital

Research output: Contribution to journal › Review Article › Research › peer-review

279 Citations (Scopus)

Abstract

Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum based therapy, the standard care for primary ovarian cancer management. A deeper understanding of the immunological basis and other potential mechanisms of action together with new dosing schedules and/or routes of administration may potentiate its clinical benefit. Newer forms of taxanes, with better safety profiles and higher intratumoural cytotoxicity, have yet to demonstrate clinical superiority over the parent compound.

Original language	English
Article number	413076
Number of pages	22
Journal	BioMed Research International
Volume	2015
DOIs	https://doi.org/10.1155/2015/413076
Publication status	Published - 2015

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10.1155/2015/413076

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AB - Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum based therapy, the standard care for primary ovarian cancer management. A deeper understanding of the immunological basis and other potential mechanisms of action together with new dosing schedules and/or routes of administration may potentiate its clinical benefit. Newer forms of taxanes, with better safety profiles and higher intratumoural cytotoxicity, have yet to demonstrate clinical superiority over the parent compound.

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Paclitaxel and its evolving role in the management of ovarian cancer

Abstract

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NHMRC Research Fellowship

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Paclitaxel and its evolving role in the management of ovarian cancer

Abstract

UN SDGs

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NHMRC Research Fellowship

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