P53 at the start of the 21st century: Lessons from elephants

Sue Haupt, Ygal Haupt

Research output: Contribution to journalReview ArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised functions of p53 relate to its cellular stress responses. In this review, we explore emerging insights into p53 activities and their functional consequences. We compare p53 in humans and elephants, in search of salient features of cancer protection.

Original languageEnglish
Article number2041
Number of pages8
JournalF1000Research
Volume6
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Cancer
  • P53
  • Tumour suppressor protein

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