P53 at the start of the 21st century: Lessons from elephants

Sue Haupt; Ygal Haupt

doi:10.12688/f1000research.12682.1

P53 at the start of the 21st century: Lessons from elephants

Sue Haupt, Ygal Haupt

Biochemistry & Molecular Biology

Research output: Contribution to journal › Review Article › Research › peer-review

16 Citations (Scopus)

Abstract

Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised functions of p53 relate to its cellular stress responses. In this review, we explore emerging insights into p53 activities and their functional consequences. We compare p53 in humans and elephants, in search of salient features of cancer protection.

Original language	English
Article number	2041
Number of pages	8
Journal	F1000Research
Volume	6
DOIs	https://doi.org/10.12688/f1000research.12682.1
Publication status	Published - 1 Jan 2017

Keywords

Cancer
P53
Tumour suppressor protein

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.12688/f1000research.12682.1

246313590-oaFinal published version, 664 KB

Cite this

@article{48997bdecc634d5cb753a3e8dbbc51be,

title = "P53 at the start of the 21st century: Lessons from elephants",

abstract = "Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised functions of p53 relate to its cellular stress responses. In this review, we explore emerging insights into p53 activities and their functional consequences. We compare p53 in humans and elephants, in search of salient features of cancer protection.",

keywords = "Cancer, P53, Tumour suppressor protein",

author = "Sue Haupt and Ygal Haupt",

year = "2017",

month = jan,

day = "1",

doi = "10.12688/f1000research.12682.1",

language = "English",

volume = "6",

journal = "F1000Research",

issn = "2046-1402",

publisher = "F1000 Research, Ltd.",

}

TY - JOUR

T1 - P53 at the start of the 21st century

T2 - Lessons from elephants

AU - Haupt, Sue

AU - Haupt, Ygal

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised functions of p53 relate to its cellular stress responses. In this review, we explore emerging insights into p53 activities and their functional consequences. We compare p53 in humans and elephants, in search of salient features of cancer protection.

AB - Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised functions of p53 relate to its cellular stress responses. In this review, we explore emerging insights into p53 activities and their functional consequences. We compare p53 in humans and elephants, in search of salient features of cancer protection.

KW - Cancer

KW - P53

KW - Tumour suppressor protein

UR - http://www.scopus.com/inward/record.url?scp=85035070533&partnerID=8YFLogxK

U2 - 10.12688/f1000research.12682.1

DO - 10.12688/f1000research.12682.1

M3 - Review Article

C2 - 29250320

AN - SCOPUS:85035070533

SN - 2046-1402

VL - 6

JO - F1000Research

JF - F1000Research

M1 - 2041

ER -

P53 at the start of the 21st century: Lessons from elephants

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Cite this