P53 at the start of the 21st century: Lessons from elephants

Sue Haupt; Ygal Haupt

doi:10.12688/f1000research.12682.1

P53 at the start of the 21st century: Lessons from elephants

Sue Haupt, Ygal Haupt

Biochemistry & Molecular Biology

Research output: Contribution to journal › Review Article › Research › peer-review

12 Citations (Scopus)

Abstract

Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised functions of p53 relate to its cellular stress responses. In this review, we explore emerging insights into p53 activities and their functional consequences. We compare p53 in humans and elephants, in search of salient features of cancer protection.

Original language	English
Article number	2041
Number of pages	8
Journal	F1000Research
Volume	6
DOIs	https://doi.org/10.12688/f1000research.12682.1
Publication status	Published - 1 Jan 2017

Keywords

Cancer
P53
Tumour suppressor protein

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.12688/f1000research.12682.1

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Cite this

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abstract = "Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised functions of p53 relate to its cellular stress responses. In this review, we explore emerging insights into p53 activities and their functional consequences. We compare p53 in humans and elephants, in search of salient features of cancer protection.",

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KW - Tumour suppressor protein

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P53 at the start of the 21st century: Lessons from elephants

Abstract

Keywords

UN SDGs

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