Abstract
Inflammation plays a fundamental role in many chronic diseases, including atherosclerosis associated cardiovascular disease. Adhesion of immune cells plays a critical role in the inflammatory response and indeed the patho physiology of inflammatory related diseases. P-selectin is an inflammatory adhesion molecule, enabling the recruitment of leukocytes to the endothelium and to activated platelets involved in the growing thrombus. P-selectin is critical in the progression of atherosclerosis as evidenced by knockout animal models where P-selectin knockout mice crossed with apoE deficient mice exhibit significantly reduced atherosclerosis and leukocyte recruitment in the plaque. A soluble form of P-selectin also exists, which may have pro-atherogenic and pro-thrombotic effects. Thus targeting of Pselectin remains a strong clinical candidate for developing novel therapeutic strategies in inflammatory diseases. This review will discuss the role of P-selectin and describe the function of P-selectin antagonists as clinical targets.
Original language | English |
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Pages (from-to) | 4113-4118 |
Number of pages | 6 |
Journal | Current Pharmaceutical Design |
Volume | 16 |
Issue number | 37 |
DOIs | |
Publication status | Published - 2010 |
Externally published | Yes |
Keywords
- Atherosclerosis
- Cellular adhesion
- Endothelium
- Inflammation
- Leukocyte
- P-selectin