Oxytocin receptor blockade and prostaglandin release in late pregnant sheep

Graham Jenkin, Danielle Buttress, Richard Harding

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7 Citations (Scopus)


The oxytocin receptor inhibitor 1-deamino-2-d-Tyr-(oET)-4-Thr-8-orn-oxytocin (CAP) was infused into late pregnant sheep. Basal and oxytocin-induced prostaglandin (PG) concentrations in maternal and fetal plasma were determined. CAP had no significant effect on maternal PGFM or PGE 2 or fetal PGF , PGFM or PGE 2 concentrations during late pregnancy or at term. PGF was not detectable in maternal peripheral plasma. CAP infusion did not affect fetal well-being. Oxytocin injection to the mother caused a significant, dose-dependent, increase in maternal plasma PGFM concentrations but did not alter maternal PGE 2 concentrations or fetal PGF and PGE 2 concentrations. The increase in maternal PGFM concentrations brought about by oxytocin injection was decreased during intrauterine infusion of CAP over the range of 12.5-100 μ/min. A rationale for the use of oxytocin receptor blockade for the prevention of premature labor is thus provided.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
Issue number1
Publication statusPublished - 1 Jan 1994


  • Fetal well-being
  • Oxytocin
  • Oxytocin receptor blockade
  • Premature labor
  • Prostaglandins

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