Oxytocin receptor blockade and prostaglandin release in late pregnant sheep

Graham Jenkin; Danielle Buttress; Richard Harding

doi:10.1016/0028-2243(94)90128-7

Oxytocin receptor blockade and prostaglandin release in late pregnant sheep

Graham Jenkin, Danielle Buttress, Richard Harding

Physiology

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

The oxytocin receptor inhibitor 1-deamino-2-d-Tyr-(oET)-4-Thr-8-orn-oxytocin (CAP) was infused into late pregnant sheep. Basal and oxytocin-induced prostaglandin (PG) concentrations in maternal and fetal plasma were determined. CAP had no significant effect on maternal PGFM or PGE ₂ or fetal PGF _2α , PGFM or PGE ₂ concentrations during late pregnancy or at term. PGF _2α was not detectable in maternal peripheral plasma. CAP infusion did not affect fetal well-being. Oxytocin injection to the mother caused a significant, dose-dependent, increase in maternal plasma PGFM concentrations but did not alter maternal PGE ₂ concentrations or fetal PGF _2α and PGE ₂ concentrations. The increase in maternal PGFM concentrations brought about by oxytocin injection was decreased during intrauterine infusion of CAP over the range of 12.5-100 μ/min. A rationale for the use of oxytocin receptor blockade for the prevention of premature labor is thus provided.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume	53
Issue number	1
DOIs	https://doi.org/10.1016/0028-2243(94)90128-7
Publication status	Published - 1 Jan 1994

Keywords

Fetal well-being
Oxytocin
Oxytocin receptor blockade
Premature labor
Prostaglandins

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10.1016/0028-2243(94)90128-7

Link to publication in Scopus

Cite this

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title = "Oxytocin receptor blockade and prostaglandin release in late pregnant sheep",

abstract = " The oxytocin receptor inhibitor 1-deamino-2-d-Tyr-(oET)-4-Thr-8-orn-oxytocin (CAP) was infused into late pregnant sheep. Basal and oxytocin-induced prostaglandin (PG) concentrations in maternal and fetal plasma were determined. CAP had no significant effect on maternal PGFM or PGE 2 or fetal PGF 2α , PGFM or PGE 2 concentrations during late pregnancy or at term. PGF 2α was not detectable in maternal peripheral plasma. CAP infusion did not affect fetal well-being. Oxytocin injection to the mother caused a significant, dose-dependent, increase in maternal plasma PGFM concentrations but did not alter maternal PGE 2 concentrations or fetal PGF 2α and PGE 2 concentrations. The increase in maternal PGFM concentrations brought about by oxytocin injection was decreased during intrauterine infusion of CAP over the range of 12.5-100 μ/min. A rationale for the use of oxytocin receptor blockade for the prevention of premature labor is thus provided.",

keywords = "Fetal well-being, Oxytocin, Oxytocin receptor blockade, Premature labor, Prostaglandins",

author = "Graham Jenkin and Danielle Buttress and Richard Harding",

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AU - Buttress, Danielle

AU - Harding, Richard

PY - 1994/1/1

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N2 - The oxytocin receptor inhibitor 1-deamino-2-d-Tyr-(oET)-4-Thr-8-orn-oxytocin (CAP) was infused into late pregnant sheep. Basal and oxytocin-induced prostaglandin (PG) concentrations in maternal and fetal plasma were determined. CAP had no significant effect on maternal PGFM or PGE 2 or fetal PGF 2α , PGFM or PGE 2 concentrations during late pregnancy or at term. PGF 2α was not detectable in maternal peripheral plasma. CAP infusion did not affect fetal well-being. Oxytocin injection to the mother caused a significant, dose-dependent, increase in maternal plasma PGFM concentrations but did not alter maternal PGE 2 concentrations or fetal PGF 2α and PGE 2 concentrations. The increase in maternal PGFM concentrations brought about by oxytocin injection was decreased during intrauterine infusion of CAP over the range of 12.5-100 μ/min. A rationale for the use of oxytocin receptor blockade for the prevention of premature labor is thus provided.

AB - The oxytocin receptor inhibitor 1-deamino-2-d-Tyr-(oET)-4-Thr-8-orn-oxytocin (CAP) was infused into late pregnant sheep. Basal and oxytocin-induced prostaglandin (PG) concentrations in maternal and fetal plasma were determined. CAP had no significant effect on maternal PGFM or PGE 2 or fetal PGF 2α , PGFM or PGE 2 concentrations during late pregnancy or at term. PGF 2α was not detectable in maternal peripheral plasma. CAP infusion did not affect fetal well-being. Oxytocin injection to the mother caused a significant, dose-dependent, increase in maternal plasma PGFM concentrations but did not alter maternal PGE 2 concentrations or fetal PGF 2α and PGE 2 concentrations. The increase in maternal PGFM concentrations brought about by oxytocin injection was decreased during intrauterine infusion of CAP over the range of 12.5-100 μ/min. A rationale for the use of oxytocin receptor blockade for the prevention of premature labor is thus provided.

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