Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx-/-) mice

Andrew L Siebel, Helen Gehring, Lenka Vodstrcil, Laura J Parry

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5 Citations (Scopus)


Relaxin decreases oxytocin-stimulated rat myometrial contractions in vitro. This study used pregnant relaxin-deficient (Rlx-/-) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium. Myometrial OTRs were significantly decreased on gestation day 18.5 in Rlx-/- mice than in Rlx+/+ mice. An increase in ERα in Rlx+/+ mice at term was correlated with a decrease in ERβ, which was not observed in Rlx-/- mice. Treatment of Rlx-/- mice with relaxin had no effect on OTR, LGR7, or ERα expression, but it caused a significant decrease in ERβs.

Original languageEnglish
Pages (from-to)104-109
Number of pages6
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 1 Jan 2005


  • Estrogen receptor
  • Myometrium
  • Oxytocin receptor

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