Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx-/-) mice

Andrew L Siebel; Helen Gehring; Lenka Vodstrcil; Laura J Parry

doi:10.1196/annals.1282.014

Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx^-/-) mice

Andrew L Siebel, Helen Gehring, Lenka Vodstrcil, Laura J Parry

Melbourne Sexual Health Clinic

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

Relaxin decreases oxytocin-stimulated rat myometrial contractions in vitro. This study used pregnant relaxin-deficient (Rlx^-/-) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium. Myometrial OTRs were significantly decreased on gestation day 18.5 in Rlx^-/- mice than in Rlx^+/+ mice. An increase in ERα in Rlx^+/+ mice at term was correlated with a decrease in ERβ, which was not observed in Rlx^-/- mice. Treatment of Rlx^-/- mice with relaxin had no effect on OTR, LGR7, or ERα expression, but it caused a significant decrease in ERβs.

Original language	English
Pages (from-to)	104-109
Number of pages	6
Journal	Annals of the New York Academy of Sciences
Volume	1041
DOIs	https://doi.org/10.1196/annals.1282.014 https://doi.org/10.1196/annals.1282.014
Publication status	Published - 1 Jan 2005

Keywords

Estrogen receptor
Myometrium
Oxytocin receptor

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Cite this

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title = "Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx-/-) mice",

abstract = "Relaxin decreases oxytocin-stimulated rat myometrial contractions in vitro. This study used pregnant relaxin-deficient (Rlx-/-) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium. Myometrial OTRs were significantly decreased on gestation day 18.5 in Rlx-/- mice than in Rlx+/+ mice. An increase in ERα in Rlx+/+ mice at term was correlated with a decrease in ERβ, which was not observed in Rlx-/- mice. Treatment of Rlx-/- mice with relaxin had no effect on OTR, LGR7, or ERα expression, but it caused a significant decrease in ERβs.",

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