Oxidative transformations of amino acids and peptides catalysed by Cytochromes P450

Max J. Cryle, Clara Brieke, Kristina Haslinger

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

15 Citations (Scopus)

Abstract

Cytochromes P450 (P450s) are a superfamily of oxidoreductases that display not only a high degree of substrate diversity across xenobiotic and secondary metabolism but also show flexibility in the oxidation chemistry that they catalyse. The oxidative transformation of amino acids and peptides by P450s represents an important collection of transformations for this enzyme class: these transformations are used in Nature to diversify the limited range of monomers available for ribosomal peptide production, as well as altering peptides to afford desired biological properties. This chapter will highlight current examples of P450-catalysed transformations of amino acids and peptides, organised by the nature of the oxidative transformation performed by the P450.

Original languageEnglish
Title of host publicationAmino Acids, Peptides and Proteins
EditorsE Farkas, M Ryadnov
Place of PublicationUK
PublisherThe Royal Society of Chemistry
Pages1-36
Number of pages36
ISBN (Print)9781849735858
DOIs
Publication statusPublished - 2013
Externally publishedYes

Publication series

NameAmino Acids, Peptides and Proteins
Volume38
ISSN (Print)1361-5904

Cite this