Oxidative Stress in Surgery

Franklin Rosenfeldt, Mark Wilson, Geraldine Lee, Christina Kure, Ruchong Ou, Lesley Braun, Judy B De Haan

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Reactive oxygen species (ROS) play both physiological and pathophysiological roles in the body. In clinical practice, oxidative stress and its counterpart, antioxidant capacity, can be measured and can guide remedial therapy. Oxidative stress can make a negative impact in all forms of major surgery including cardiac surgery, general surgery, trauma surgery, orthopedic surgery, and plastic surgery. Many and various therapies aimed at reducing oxidative stress in surgery have been tried with variable results. We conclude that in surgical patients, the assessment of oxidative stress, improving understanding of its role, both positive and negative, and devising appropriate therapies are of great clinical importance and represent fruitful fields for further research.
Original languageEnglish
Title of host publicationSystems Biology of Free Radicals and Antioxidants
EditorsIsmail Laher
Place of PublicationBerlin Germany
PublisherSpringer
Pages3929-3946
Number of pages17
ISBN (Electronic)9783642300189
ISBN (Print)9783642300172, 9783642300196
DOIs
Publication statusPublished - 2014

Keywords

  • Antioxidant capacity
  • Free radicals
  • Oxidative stress
  • Reactive oxygen species
  • Surgery

Cite this

Rosenfeldt, F., Wilson, M., Lee, G., Kure, C., Ou, R., Braun, L., & De Haan, J. B. (2014). Oxidative Stress in Surgery. In I. Laher (Ed.), Systems Biology of Free Radicals and Antioxidants (pp. 3929-3946). Berlin Germany: Springer. https://doi.org/10.1007/978-3-642-30018-9_177
Rosenfeldt, Franklin ; Wilson, Mark ; Lee, Geraldine ; Kure, Christina ; Ou, Ruchong ; Braun, Lesley ; De Haan, Judy B. / Oxidative Stress in Surgery. Systems Biology of Free Radicals and Antioxidants. editor / Ismail Laher. Berlin Germany : Springer, 2014. pp. 3929-3946
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Rosenfeldt, F, Wilson, M, Lee, G, Kure, C, Ou, R, Braun, L & De Haan, JB 2014, Oxidative Stress in Surgery. in I Laher (ed.), Systems Biology of Free Radicals and Antioxidants. Springer, Berlin Germany, pp. 3929-3946. https://doi.org/10.1007/978-3-642-30018-9_177

Oxidative Stress in Surgery. / Rosenfeldt, Franklin ; Wilson, Mark ; Lee, Geraldine ; Kure, Christina; Ou, Ruchong; Braun, Lesley; De Haan, Judy B.

Systems Biology of Free Radicals and Antioxidants. ed. / Ismail Laher. Berlin Germany : Springer, 2014. p. 3929-3946.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

TY - CHAP

T1 - Oxidative Stress in Surgery

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AU - Kure, Christina

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AU - Braun, Lesley

AU - De Haan, Judy B

PY - 2014

Y1 - 2014

N2 - Reactive oxygen species (ROS) play both physiological and pathophysiological roles in the body. In clinical practice, oxidative stress and its counterpart, antioxidant capacity, can be measured and can guide remedial therapy. Oxidative stress can make a negative impact in all forms of major surgery including cardiac surgery, general surgery, trauma surgery, orthopedic surgery, and plastic surgery. Many and various therapies aimed at reducing oxidative stress in surgery have been tried with variable results. We conclude that in surgical patients, the assessment of oxidative stress, improving understanding of its role, both positive and negative, and devising appropriate therapies are of great clinical importance and represent fruitful fields for further research.

AB - Reactive oxygen species (ROS) play both physiological and pathophysiological roles in the body. In clinical practice, oxidative stress and its counterpart, antioxidant capacity, can be measured and can guide remedial therapy. Oxidative stress can make a negative impact in all forms of major surgery including cardiac surgery, general surgery, trauma surgery, orthopedic surgery, and plastic surgery. Many and various therapies aimed at reducing oxidative stress in surgery have been tried with variable results. We conclude that in surgical patients, the assessment of oxidative stress, improving understanding of its role, both positive and negative, and devising appropriate therapies are of great clinical importance and represent fruitful fields for further research.

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KW - Free radicals

KW - Oxidative stress

KW - Reactive oxygen species

KW - Surgery

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DO - 10.1007/978-3-642-30018-9_177

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BT - Systems Biology of Free Radicals and Antioxidants

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CY - Berlin Germany

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Rosenfeldt F, Wilson M, Lee G, Kure C, Ou R, Braun L et al. Oxidative Stress in Surgery. In Laher I, editor, Systems Biology of Free Radicals and Antioxidants. Berlin Germany: Springer. 2014. p. 3929-3946 https://doi.org/10.1007/978-3-642-30018-9_177