Oxidative Stress in Surgery

Franklin Rosenfeldt, Mark Wilson, Geraldine Lee, Christina Kure, Ruchong Ou, Lesley Braun, Judy B De Haan

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review


Reactive oxygen species (ROS) play both physiological and pathophysiological roles in the body. In clinical practice, oxidative stress and its counterpart, antioxidant capacity, can be measured and can guide remedial therapy. Oxidative stress can make a negative impact in all forms of major surgery including cardiac surgery, general surgery, trauma surgery, orthopedic surgery, and plastic surgery. Many and various therapies aimed at reducing oxidative stress in surgery have been tried with variable results. We conclude that in surgical patients, the assessment of oxidative stress, improving understanding of its role, both positive and negative, and devising appropriate therapies are of great clinical importance and represent fruitful fields for further research.
Original languageEnglish
Title of host publicationSystems Biology of Free Radicals and Antioxidants
EditorsIsmail Laher
Place of PublicationBerlin Germany
Number of pages17
ISBN (Electronic)9783642300189
ISBN (Print)9783642300172, 9783642300196
Publication statusPublished - 2014


  • Antioxidant capacity
  • Free radicals
  • Oxidative stress
  • Reactive oxygen species
  • Surgery

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