Oxidative stress and advanced glycation in diabetic nephropathy

Melinda T. Coughlan, Amy L. Mibus, Josephine M. Forbes

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

50 Citations (Scopus)

Abstract

Nephropathy remains a significant cause of morbidity and mortality in the diabetic population and is the leading cause of end-stage renal failure in the Western World. As a result of the diabetic milieu, increased generation of reactive oxygen species (ROS) is thought to play a key role in the progression of diabetic nephropathy. Recent experimental studies have suggested that the receptor for advanced glycation end products (RAGE), which is central to the advanced glycation pathway, may mediate renal structural and functional damage via oxidative stress. This review focuses on how RAGE and subsequent ROS generation play a deleterious role in the diabetic kidney, promoting cross-talk among signaling pathways, ultimately leading to renal dysfunction.

Original languageEnglish
Title of host publicationThe Maillard Reaction Recent Advances in Food and Biomedical Sciences
PublisherWiley-Blackwell
Pages190-193
Number of pages4
ISBN (Print)9781573317, 9789781573316
DOIs
Publication statusPublished - 1 Jan 2008
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1126
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Advanced glycation end products (AGEs)
  • Diabetic nephropathy
  • Reactive oxygen species (ROS)
  • Receptor for advanced glycation end products (RAGE)

Cite this