Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions

Gregory M. Cook, Kiel Hards, Elyse Dunn, Adam Heikal, Yoshio Nakatani, Christopher Andrew Greening, Dean C. Crick, Fabio L. Fontes, Kevin Pethe, Erik Hasenoehrl, Michael Berney

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Abstract

The genus Mycobacterium comprises a group of obligately aerobic bacteria that have adapted to inhabit a wide range of intracellular and extracellular environments. Fundamental to this adaptation is the ability to respire and generate energy from variable sources and to sustain metabolism in the absence of growth. The pioneering work of Brodie and colleagues on Mycobacterium phlei established much of the primary information on the electron transport chain and oxidative phosphorylation system in mycobacteria. Mycobacteria can only generate sufficient energy for growth by coupling the oxidation of electron donors derived from organic carbon catabolism (e.g., NADH, succinate, malate) to the reduction of O 2 as a terminal electron acceptor. Mycobacterial genome sequencing revealed that branched pathways exist in mycobacterial species for electron transfer from many low-potential reductants, via quinol, to oxygen.
Original languageEnglish
Title of host publicationTuberculosis and the Tubercle Bacillus
EditorsWilliam R Jacobs, Jr., Helen McShane, Valerie Mizrahi, Ian M Orme
Place of PublicationWashington DC USA
PublisherAmerican Society for Microbiology
Chapter14
Pages295-316
Number of pages22
Edition2nd
ISBN (Electronic)9781555819569
ISBN (Print)9781555819552
DOIs
Publication statusPublished - 2018

Cite this

Cook, G. M., Hards, K., Dunn, E., Heikal, A., Nakatani, Y., Greening, C. A., ... Berney, M. (2018). Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions. In W. R. Jacobs, Jr., H. McShane, V. Mizrahi, & I. M. Orme (Eds.), Tuberculosis and the Tubercle Bacillus (2nd ed., pp. 295-316). Washington DC USA: American Society for Microbiology. https://doi.org/10.1128/microbiolspec.TBTB2-0014-2016