The genus Mycobacterium comprises a group of obligately aerobic bacteria that have adapted to inhabit a wide range of intracellular and extracellular environments. Fundamental to this adaptation is the ability to respire and generate energy from variable sources and to sustain metabolism in the absence of growth. The pioneering work of Brodie and colleagues on Mycobacterium phlei established much of the primary information on the electron transport chain and oxidative phosphorylation system in mycobacteria. Mycobacteria can only generate sufficient energy for growth by coupling the oxidation of electron donors derived from organic carbon catabolism (e.g., NADH, succinate, malate) to the reduction of O 2 as a terminal electron acceptor. Mycobacterial genome sequencing revealed that branched pathways exist in mycobacterial species for electron transfer from many low-potential reductants, via quinol, to oxygen.
|Title of host publication||Tuberculosis and the Tubercle Bacillus|
|Editors||William R Jacobs, Jr., Helen McShane, Valerie Mizrahi, Ian M Orme|
|Place of Publication||Washington DC USA|
|Publisher||American Society for Microbiology|
|Number of pages||22|
|Publication status||Published - 2018|
Cook, G. M., Hards, K., Dunn, E., Heikal, A., Nakatani, Y., Greening, C. A.
, ... Berney, M. (2018). Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions
. In W. R. Jacobs, Jr., H. McShane, V. Mizrahi, & I. M. Orme (Eds.), Tuberculosis and the Tubercle Bacillus
(2nd ed., pp. 295-316). Washington DC USA: American Society for Microbiology. https://doi.org/10.1128/microbiolspec.TBTB2-0014-2016