Oxidative Coupling and Self-Assembly of Polyphenols for the Development of Novel Biomaterials

Jyoti Pal, Manu Sharma, Abhishek Tiwari, Varsha Tiwari, Manish Kumar, Ajay Sharma, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Gaurav Gupta, Vinoth Kumarasamy, Vetriselvan Subramaniyan

Research output: Contribution to journalReview ArticleResearchpeer-review


In recent years, the development of biomaterials from green organic sources with nontoxicity and hyposensitivity has been explored for a wide array of biotherapeutic applications. Polyphenolic compounds have unique structural features, and self-assembly by oxidative coupling allows molecular species to rearrange into complex biomaterial that can be used for multiple applications. Self-assembled polyphenolic structures, such as hollow spheres, can be designed to respond to various chemical and physical stimuli that can release therapeutic drugs smartly. The self-assembled metallic-phenol network (MPN) has been used for modulating interfacial properties and designing biomaterials, and there are several advantages and challenges associated with such biomaterials. This review comprehensively summarizes current challenges and prospects of self-assembled polyphenolic hollow spheres and MPN coatings and self-assembly for biomedical applications.

Original languageEnglish
Pages (from-to)19741–19755
Number of pages15
JournalACS Omega
Issue number18
Publication statusPublished - 26 Apr 2023

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