Oxidative & nitrosative stress in depression: why so much stress?

Steven Moylan, Michael Berk, Olivia Dean, Yuval Samuni, Lana Williams, Adrienne O'Neil, Amie Hayley, Julie Anne Pasco, George M Anderson, Felice N Jacka, Michael H Maes

Research output: Contribution to journalArticleResearchpeer-review

230 Citations (Scopus)


Many studies support a crucial role for oxidative nitrosative stress (O NS) in the pathophysiology of unipolar and bipolar depression. These disorders are characterized inter alia by lowered antioxidant defenses, including: lower levels of zinc, coenzyme Q10, vitamin E and glutathione increased lipid peroxidation; damage to proteins, DNA and mitochondria; secondary autoimmune responses directed against redox modified nitrosylated proteins and oxidative specific epitopes. This review examines and details a model through which a complex series of environmental factors and biological pathways contribute to increased redox signaling and consequently increased O NS in mood disorders. This multi-step process highlights the potential for future interventions that encompass a diverse range of environmental and molecular targets in the treatment of depression.
Original languageEnglish
Pages (from-to)46 - 62
Number of pages17
JournalNeuroscience and Biobehavioral Reviews
Publication statusPublished - 2014

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