TY - JOUR
T1 - Overview of chemical imaging methods to address biological questions
AU - da Cunha, Marcel Menezes Lyra
AU - Trepout, Sylvain
AU - Messaoudi, Cédric
AU - Wu, Ting Di
AU - Ortega, Richard
AU - Guerquin-Kern, Jean Luc
AU - Marco, Sergio
N1 - Funding Information:
This work was supported by Agence Nationale pour la Recherche (ANR) program PIRIBIO (ANR-09-PIRI-0029-01) for the biological study. Technical developments required for SIMS-EFTEM correlative imaging have been supported by ANR-11-BSV8-016. MML da Cunha is supported by Fundação de Amparo a Pesquisa Carlos Chagas Filho – FAPERJ and Conselho Nacional de Pesquisa – CNPq, Brazil. We also acknowledge the PICT-IBiSA for providing access to chemical imaging equipment.
Publisher Copyright:
© 2016 The Authors.
PY - 2016/5
Y1 - 2016/5
N2 - Chemical imaging offers extensive possibilities for better understanding of biological systems by allowing the identification of chemical components at the tissue, cellular, and subcellular levels. In this review, we introduce modern methods for chemical imaging that can be applied to biological samples. This work is mainly addressed to the biological sciences community and includes the bases of different technologies, some examples of its application, as well as an introduction to approaches on combining multimodal data.
AB - Chemical imaging offers extensive possibilities for better understanding of biological systems by allowing the identification of chemical components at the tissue, cellular, and subcellular levels. In this review, we introduce modern methods for chemical imaging that can be applied to biological samples. This work is mainly addressed to the biological sciences community and includes the bases of different technologies, some examples of its application, as well as an introduction to approaches on combining multimodal data.
KW - EELS
KW - EFTEM
KW - NanoSIMS
KW - PIXE
KW - STEM
KW - Synchrotron radiation micro-analysis
UR - http://www.scopus.com/inward/record.url?scp=84959019287&partnerID=8YFLogxK
U2 - 10.1016/j.micron.2016.02.005
DO - 10.1016/j.micron.2016.02.005
M3 - Review Article
C2 - 26922256
AN - SCOPUS:84959019287
SN - 0968-4328
VL - 84
SP - 23
EP - 36
JO - Micron
JF - Micron
ER -