Overcoming insulin resistance with ciliary neurotrophic factor

Tamara L. Allen, Vance B Matthews, Mark A. Febbraio

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

14 Citations (Scopus)

Abstract

The incidence of obesity and related co-morbidities such as insulin resistance, dyslipidemia and hypertension are increasing at an alarming rate worldwide. Current interventions seem ineffective to halt this progression. With the failure of leptin as an anti-obesity therapeutic, ciliary neurotrophic factor (CNTF) has proven efficacious in models of obesity and leptin resistance, where leptin proved ineffective. CNTF is a gp130 ligand that has been found to act centrally and peripherally to promote weight loss and insulin sensitivity in both human and rodent models. Future research into novel gp130 ligands may offer new candidates for obesity-related drug therapy.

Original languageEnglish
Title of host publicationDiabetes - Perspectives in Drug Therapy
PublisherSpringer
Pages179-199
Number of pages21
Volume203
ISBN (Print)9783642172137
DOIs
Publication statusPublished - 2011
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
Volume203
ISSN (Print)01712004

Keywords

  • Ciliary Neurotrophic Factor
  • gp130 Ligands
  • Insulin Resistance
  • Leptin
  • Obesity

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