Ovarian follicle populations of the rat express TGF-β signalling pathways

Ann E. Drummond, Mitzi Dyson, Minh Tan Le, Jean Francois Ethier, Jock K. Findlay

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

The transforming growth factor-β (TGF-β) superfamily comprises more than 40 members, classified on the basis of structural similarity. These factors elicit a diverse range of cellular responses in insects, nematodes and vertebrates, via serine/threonine kinase receptors and intracellular Smad proteins, which when activated mediate gene transcription. Some members of the superfamily, notably activin, TGF-β, GDF-9 and the bone morphogenetic proteins have been shown to influence ovarian function. Despite these actions, TGF-β superfamily signalling pathways and specifically those within follicle population subtypes, have been poorly characterised in the ovary. We have shown that the ovary contains type I and II receptors and Smads, which enable it to transduce signals in response to TGF-β superfamily members. It remains to be established however, as to which follicle subtypes these pathways are active in.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume202
Issue number1-2
DOIs
Publication statusPublished - 28 Apr 2003
Externally publishedYes

Keywords

  • Activin
  • Betaglycan
  • Ovary
  • Receptor
  • Smad
  • Transforming growth factor-β

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