Ovarian actions of estrogen receptor-β: An update

Ann E. Drummond, Peter J. Fuller

Research output: Contribution to journalReview ArticleResearchpeer-review

33 Citations (Scopus)

Abstract

Estrogen is essential for folliculogenesis with independent roles attributed to each of the two estrogen receptors (ERs). ER, expressed predominantly by the ovarian granulosa cells, is required for antrum formation, preovulatory follicle maturation, expression of genes involved in ovarian differentiation (luteinizing hormone, aromatase, etc.), and follicle rupture during ovulation. Ovulatory dysfunction is associated with polymorphisms of the ER gene, and endocrine disruptors that selectively activate ER cause reproductive dysfunction and impairment fertility. ER may also exhibit antitumorigenic properties, with a decline in ER levels in epithelial ovarian cancers associated with more severe disease and poor prognosis. In this review, we examine the models that have been used to elucidate the roles ER plays in the ovary and consider the clinical consequences of altered ER expression or inappropriate activation of ER signaling.

Original languageEnglish
Pages (from-to)32-38
Number of pages7
JournalSeminars in Reproductive Medicine
Volume30
Issue number1
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • cancer
  • environmental estrogens
  • estrogen
  • estrogen receptor
  • ovary

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