TY - JOUR
T1 - Outcomes of singleton births after blastocyst versus nonblastocyst transfer in assisted reproductive technology
AU - Fernando, Dhanushi Thilakshana
AU - Halliday, Jane
AU - Breheny, Sue
AU - Healy, David Lindsay
PY - 2012
Y1 - 2012
N2 - Objective: To compare obstetric and perinatal outcomes of singleton births after assisted reproductive technology (ART) with blastocyst transfer (days 5
to 6) versus nonblastocyst transfer (days 2 to 4).
Design: Retrospective cohort study.
Setting: Monash IVF.
Patient(s): 4,202 women who conceived using in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) between 2004 and 2009.
Intervention(s): Records analysis of fresh and frozen-thawed embryo transfers resulting in singleton births of at least 20 weeksa?? gestation.
Main Outcome Measure(s): Perinatal outcomes: preterm birth, low birthweight, very low birthweight, small for gestational age, large for gestational
age, preeclampsia, antepartum hemorrhage, placental abruption, placenta previa, and postpartum hemorrhage; and covariates: maternal age, year of
birth of the baby, private health insurance status, maternal body mass index, smoking status, parity, gender of baby, and variations in treatment
procedures.
Result(s): Multivariate analysis found no statistically significant difference between transfers on days 5 and 6 and days 2 and 4 for all maternal
and perinatal outcomes. There were modest increases in the adjusted odds ratios for preeclampsia (adjusted odds ratio 1.72, 99 confidence interval
0.93a??3.20) and placenta previa (1.65, 0.92a??2.98).
Conclusion(s): Obstetric and perinatal outcomes after blastocyst transfer on days 5 to 6 are similar when compared with embryo cleavage-stage
transfers on days 2 to 4.
AB - Objective: To compare obstetric and perinatal outcomes of singleton births after assisted reproductive technology (ART) with blastocyst transfer (days 5
to 6) versus nonblastocyst transfer (days 2 to 4).
Design: Retrospective cohort study.
Setting: Monash IVF.
Patient(s): 4,202 women who conceived using in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) between 2004 and 2009.
Intervention(s): Records analysis of fresh and frozen-thawed embryo transfers resulting in singleton births of at least 20 weeksa?? gestation.
Main Outcome Measure(s): Perinatal outcomes: preterm birth, low birthweight, very low birthweight, small for gestational age, large for gestational
age, preeclampsia, antepartum hemorrhage, placental abruption, placenta previa, and postpartum hemorrhage; and covariates: maternal age, year of
birth of the baby, private health insurance status, maternal body mass index, smoking status, parity, gender of baby, and variations in treatment
procedures.
Result(s): Multivariate analysis found no statistically significant difference between transfers on days 5 and 6 and days 2 and 4 for all maternal
and perinatal outcomes. There were modest increases in the adjusted odds ratios for preeclampsia (adjusted odds ratio 1.72, 99 confidence interval
0.93a??3.20) and placenta previa (1.65, 0.92a??2.98).
Conclusion(s): Obstetric and perinatal outcomes after blastocyst transfer on days 5 to 6 are similar when compared with embryo cleavage-stage
transfers on days 2 to 4.
UR - http://www.sciencedirect.com/science/article/pii/S0015028211029165
U2 - 10.1016/j.fertnstert.2011.12.032
DO - 10.1016/j.fertnstert.2011.12.032
M3 - Article
VL - 97
SP - 579
EP - 584
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 3
ER -