Outcomes of ambulatory rehabilitation programmes following botulinum toxin for spasticity in adults with stroke

Marina Demetrios, Alexandra Gorelik, Julie Louie, Caroline Anne Brand, Ian J Baguley, Fary Khan

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

Objective: To examine the benefits of high intensity ambulatory rehabilitation programmes over usual care following botulinum toxin A (BoNT-A) for post-stroke spasticity in Australian adults.Design: Prospective single centre, controlled clinical trial. Participants: Fifty-nine adults, median 61 years old and 2.5 years following stroke.Methods: Participants were dichotomised into high intensity ambulatory rehabilitation programmes (= 3 ? 1-h weekly sessions for approximately 10 weeks) or usual care programmes (= 2 ? 1-h weekly sessions) following BoNT-A injections for spasticity. A blinded assessor completed outcomes at 0 (baseline), 6, 12 and 24 weeks. Primary endpoints: proportion of participants achieving = 50 of their goals (using Goal Attainment Scaling: GAS) and GAS T-score change at 12 weeks. Secondary outcomes: Modified Ashworth Scale (MAS), participant satisfaction, activity/participation measures and caregiver burden.Results: Both groups showed significant improvement in goal attainment and participant satisfaction up to 24 weeks, with no overall between-group significant differences. There was, however, a statistical trend (p = 0.052) for participants to achieve more upper limb goals in the high intensity therapy group. GAS and satisfaction benefits persisted beyond the duration of spasticity reduction as measured by MAS.Conclusions: While patient-centred outcomes following BoNT-A injections for post-stroke spasticity were not influenced by intensity of ambulatory rehabilitation programmes, there was a trend for high intensity therapy to be associated with greater upper limb goal attainment. This suggests that the effects of more intensive therapy may be a modifier of the black box of rehabilitation; however, further research is required to evaluate this effect and determine which elements of therapy programmes optimise post-BoNT-A outcomes.
Original languageEnglish
Pages (from-to)730 - 737
Number of pages8
JournalJournal of Rehabilitation Medicine
Volume46
Issue number8
DOIs
Publication statusPublished - 2014

Cite this

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title = "Outcomes of ambulatory rehabilitation programmes following botulinum toxin for spasticity in adults with stroke",
abstract = "Objective: To examine the benefits of high intensity ambulatory rehabilitation programmes over usual care following botulinum toxin A (BoNT-A) for post-stroke spasticity in Australian adults.Design: Prospective single centre, controlled clinical trial. Participants: Fifty-nine adults, median 61 years old and 2.5 years following stroke.Methods: Participants were dichotomised into high intensity ambulatory rehabilitation programmes (= 3 ? 1-h weekly sessions for approximately 10 weeks) or usual care programmes (= 2 ? 1-h weekly sessions) following BoNT-A injections for spasticity. A blinded assessor completed outcomes at 0 (baseline), 6, 12 and 24 weeks. Primary endpoints: proportion of participants achieving = 50 of their goals (using Goal Attainment Scaling: GAS) and GAS T-score change at 12 weeks. Secondary outcomes: Modified Ashworth Scale (MAS), participant satisfaction, activity/participation measures and caregiver burden.Results: Both groups showed significant improvement in goal attainment and participant satisfaction up to 24 weeks, with no overall between-group significant differences. There was, however, a statistical trend (p = 0.052) for participants to achieve more upper limb goals in the high intensity therapy group. GAS and satisfaction benefits persisted beyond the duration of spasticity reduction as measured by MAS.Conclusions: While patient-centred outcomes following BoNT-A injections for post-stroke spasticity were not influenced by intensity of ambulatory rehabilitation programmes, there was a trend for high intensity therapy to be associated with greater upper limb goal attainment. This suggests that the effects of more intensive therapy may be a modifier of the black box of rehabilitation; however, further research is required to evaluate this effect and determine which elements of therapy programmes optimise post-BoNT-A outcomes.",
author = "Marina Demetrios and Alexandra Gorelik and Julie Louie and Brand, {Caroline Anne} and Baguley, {Ian J} and Fary Khan",
year = "2014",
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language = "English",
volume = "46",
pages = "730 -- 737",
journal = "Journal of Rehabilitation Medicine",
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Outcomes of ambulatory rehabilitation programmes following botulinum toxin for spasticity in adults with stroke. / Demetrios, Marina; Gorelik, Alexandra; Louie, Julie; Brand, Caroline Anne; Baguley, Ian J; Khan, Fary.

In: Journal of Rehabilitation Medicine, Vol. 46, No. 8, 2014, p. 730 - 737.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Outcomes of ambulatory rehabilitation programmes following botulinum toxin for spasticity in adults with stroke

AU - Demetrios, Marina

AU - Gorelik, Alexandra

AU - Louie, Julie

AU - Brand, Caroline Anne

AU - Baguley, Ian J

AU - Khan, Fary

PY - 2014

Y1 - 2014

N2 - Objective: To examine the benefits of high intensity ambulatory rehabilitation programmes over usual care following botulinum toxin A (BoNT-A) for post-stroke spasticity in Australian adults.Design: Prospective single centre, controlled clinical trial. Participants: Fifty-nine adults, median 61 years old and 2.5 years following stroke.Methods: Participants were dichotomised into high intensity ambulatory rehabilitation programmes (= 3 ? 1-h weekly sessions for approximately 10 weeks) or usual care programmes (= 2 ? 1-h weekly sessions) following BoNT-A injections for spasticity. A blinded assessor completed outcomes at 0 (baseline), 6, 12 and 24 weeks. Primary endpoints: proportion of participants achieving = 50 of their goals (using Goal Attainment Scaling: GAS) and GAS T-score change at 12 weeks. Secondary outcomes: Modified Ashworth Scale (MAS), participant satisfaction, activity/participation measures and caregiver burden.Results: Both groups showed significant improvement in goal attainment and participant satisfaction up to 24 weeks, with no overall between-group significant differences. There was, however, a statistical trend (p = 0.052) for participants to achieve more upper limb goals in the high intensity therapy group. GAS and satisfaction benefits persisted beyond the duration of spasticity reduction as measured by MAS.Conclusions: While patient-centred outcomes following BoNT-A injections for post-stroke spasticity were not influenced by intensity of ambulatory rehabilitation programmes, there was a trend for high intensity therapy to be associated with greater upper limb goal attainment. This suggests that the effects of more intensive therapy may be a modifier of the black box of rehabilitation; however, further research is required to evaluate this effect and determine which elements of therapy programmes optimise post-BoNT-A outcomes.

AB - Objective: To examine the benefits of high intensity ambulatory rehabilitation programmes over usual care following botulinum toxin A (BoNT-A) for post-stroke spasticity in Australian adults.Design: Prospective single centre, controlled clinical trial. Participants: Fifty-nine adults, median 61 years old and 2.5 years following stroke.Methods: Participants were dichotomised into high intensity ambulatory rehabilitation programmes (= 3 ? 1-h weekly sessions for approximately 10 weeks) or usual care programmes (= 2 ? 1-h weekly sessions) following BoNT-A injections for spasticity. A blinded assessor completed outcomes at 0 (baseline), 6, 12 and 24 weeks. Primary endpoints: proportion of participants achieving = 50 of their goals (using Goal Attainment Scaling: GAS) and GAS T-score change at 12 weeks. Secondary outcomes: Modified Ashworth Scale (MAS), participant satisfaction, activity/participation measures and caregiver burden.Results: Both groups showed significant improvement in goal attainment and participant satisfaction up to 24 weeks, with no overall between-group significant differences. There was, however, a statistical trend (p = 0.052) for participants to achieve more upper limb goals in the high intensity therapy group. GAS and satisfaction benefits persisted beyond the duration of spasticity reduction as measured by MAS.Conclusions: While patient-centred outcomes following BoNT-A injections for post-stroke spasticity were not influenced by intensity of ambulatory rehabilitation programmes, there was a trend for high intensity therapy to be associated with greater upper limb goal attainment. This suggests that the effects of more intensive therapy may be a modifier of the black box of rehabilitation; however, further research is required to evaluate this effect and determine which elements of therapy programmes optimise post-BoNT-A outcomes.

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DO - 10.2340/16501977-1842

M3 - Article

VL - 46

SP - 730

EP - 737

JO - Journal of Rehabilitation Medicine

JF - Journal of Rehabilitation Medicine

SN - 1650-1977

IS - 8

ER -