Outcome of preterm and term neonates of mothers with malignant diseases diagnosed during pregnancy

Doris Fischer, Andre Ahr, Birgit Schaefer, Alex Veldman, Rolf Schloesser

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Objective. To investigate the outcome of preterm and term neonates born to mothers with malignant diseases diagnosed during pregnancy. Methods. A retrospective analysis with a matched-paired control group in a third level obstetric department and third level neonatal department of the University Hospital Frankfurt. Patients were preterm and term neonates from mothers with oncologic diseases diagnosed during pregnancy and matched-paired preterm and term neonates from healthy mothers. Measurements and results. Nineteen preterm and three term (1 x twins) neonates from 21 mothers with oncologic diseases and matched-paired neonates from 21 healthy mothers were included. With the exception of one case, pregnancy was terminated because of the necessity for maternal oncological treatment. Children from mothers with malignant diseases had a significantly lower birth weight and a tendency towards a higher incidence of high-grade respiratory distress syndrome. No significant differences concerning Apgar scores, red blood cell (RBC), white blood cell (WBC), and platelet (PLT) counts postpartum, and duration of hospital days between the two groups of neonates were observed. Conclusion. Direct perinatal outcome of preterm or term neonates from mothers with malignant diseases diagnosed during ongoing intact pregnancy does not differ from the outcome of a comparable group of neonates from healthy mothers. This might be in contrast to the long-term outcome of this special patient group. In our study we could find no elevated mortality in neonates where pregnancy was terminated because of the need for maternal chemotherapeutic therapy.

Original languageEnglish
Pages (from-to)101-103
Number of pages3
JournalThe Journal of Maternal-Fetal and Neonatal Medicine
Volume19
Issue number2
DOIs
Publication statusPublished - 1 Feb 2006
Externally publishedYes

Keywords

  • Cancer in pregnancy
  • Cytotoxic agents
  • Neonatal outcome
  • Prematurity

Cite this