Osteoprotegerin increases in metabolic syndrome and promotes adipose tissue proinflammatory changes

Stella Bernardi, Bruno Fabris, Merlin Thomas, Barbara Toffoli, Christos Tikellis, Riccardo Candido, Cristiana Catena, Paolo Mulatero, Fabio Barbone, Oriano Radillo, Giorgio Zauli, Paola Secchiero

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29 Citations (Scopus)

Abstract

Background: Inflammation is believed to link obesity to insulin resistance, as in the setting of metabolic syndrome (MetS). Osteoprotegerin (OPG) is a soluble protein that seems to exert proatherogenic and prodiabetogenic effects. This study aims at determining OPG levels in MetS and whether OPG might contribute to MetS development and progression. Methodology/principal findings: Circulating OPG was measured in 46 patients with MetS and 63 controls, and was found significantly elevated in those with MetS. In addition, circulating and tissue OPG was significantly increased in high-fat diet (HFD) fed C57BL6 mice, which is one of the animal models for the study of MetS. To evaluate the consequences of OPG elevation, we delivered this protein to C57BL6 mice, finding that it promoted systemic and adipose tissue proinflammatory changes in association with metabolic abnormalities. Conclusions/significance: These data suggest that OPG may trigger adipose tissue proinflammatory changes in MetS/HFD-induced obesity. 

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalMolecular and Cellular Endocrinology
Volume394
Issue number1-2
DOIs
Publication statusPublished - 25 Aug 2014
Externally publishedYes

Keywords

  • Adipose tissue
  • High-fat diet
  • Inflammation
  • Metabolic syndrome
  • Osteoprotegerin

Cite this

Bernardi, S., Fabris, B., Thomas, M., Toffoli, B., Tikellis, C., Candido, R., Catena, C., Mulatero, P., Barbone, F., Radillo, O., Zauli, G., & Secchiero, P. (2014). Osteoprotegerin increases in metabolic syndrome and promotes adipose tissue proinflammatory changes. Molecular and Cellular Endocrinology, 394(1-2), 13-20. https://doi.org/10.1016/j.mce.2014.06.004