Osteonecrosis of the jaw

Philip N. Sambrook, Peter Ebeling

Research output: Contribution to journalReview ArticleOtherpeer-review

17 Citations (Scopus)


Bisphosphonates are effective therapy for osteoporosis, Paget's disease, and metastatic bone disease. Generally, the side effects of bisphosphonates are minimal. Recently, an uncommon adverse reaction affecting the maxilla or mandible, called osteonecrosis of the jaw, has been reported, especially in those patients receiving high doses of bisphosphonates in the oncology setting. Regarding doses used to treat osteoporosis, clinicians must keep the very small potential absolute risk of jaw osteonecrosis in perspective and consider it in relation to the demonstrated benefit of bisphosphonates. Still, in a very small number of patients taking bisphosphonates, intractable, painful, nonhealing exposed bone may occur following dental extractions or denture irritation.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalCurrent Rheumatology Reports (Print)
Issue number2
Publication statusPublished - 1 Apr 2008
Externally publishedYes

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