Osteohematopoietic stem cell niches in bone marrow

Samiksha Wasnik, Abhilasha Tiwari, Mark Kirkland, Gobal Pande

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

12 Citations (Scopus)

Abstract

In adult mammals, maturation of blood and bone cells from their respective progenitors occurs in the bone marrow. The marrow region contains many progenitor and stem cell types that are confined by their biochemical and cellular microenvironments, referred to as stem cell niches. The unique properties of each niche assist the survival, proliferation, migration, and differentiation of that particular stem or progenitor cell type. Among the different niches of the bone marrow, our understanding of the osteohematopoietic niche is the most complete. Its properties, described in this chapter, are a model for studying adult stem cell differentiation, but a lot remains unknown. Our improved understanding of hematopoietic stem cell biology and its relationship with the properties of these niches are critical in the effective and safe use of these cells in regenerative medicine. Here, we review the current knowledge on the properties of these niches and suggest how the potential of hematopoietic progenitors can be utilized in regenerative medicine.
Original languageEnglish
Title of host publicationInternational Review of Cell and Molecular Biology
EditorsKwang W Jeon
Place of PublicationWaltham MA USA
PublisherElsevier
Pages95 - 133
Number of pages39
Volume298
Edition1st
ISBN (Print)9780123943095
DOIs
Publication statusPublished - 31 Dec 2012
Externally publishedYes

Publication series

NameInternational Review of Cell and Molecular Biology
PublisherElsevier
Volume298
ISSN (Electronic)1937-6448

Cite this

Wasnik, S., Tiwari, A., Kirkland, M., & Pande, G. (2012). Osteohematopoietic stem cell niches in bone marrow. In K. W. Jeon (Ed.), International Review of Cell and Molecular Biology (1st ed., Vol. 298, pp. 95 - 133). (International Review of Cell and Molecular Biology; Vol. 298). Waltham MA USA: Elsevier. https://doi.org/10.1016/B978-0-12-394309-5.00003-1