Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia

Muzaffer Kaser; Fruzsina Soltesz; Philip Lawrence; Sam Miller; Chris M Dodds; Rodney James Croft; Robert B Dudas; Rashid Zaman; Emilio Fernandez-Egea; Ulrich Muller; Anna M Dean; Edward Bullmore; Pradeep Jonathan Nathan

doi:10.1371/journal.pone.0083255

Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia

Muzaffer Kaser
, Fruzsina Soltesz
, Philip Lawrence
, Sam Miller
, Chris M Dodds
, Rodney James Croft
, Robert B Dudas
, Rashid Zaman
, Emilio Fernandez-Egea
, Ulrich Muller
, Anna M Dean
, Edward Bullmore
, Pradeep Jonathan Nathan

School of Psychological Sciences

Research output: Contribution to journal › Article › Research › peer-review

37 Citations (Scopus)

Abstract

Impairments in mismatch negativity (MMN) generation have been consistently reported in patients with schizophrenia. However, underlying oscillatory activity of MMN deficits in schizophrenia and the relationship with cognitive impairments have not been investigated in detail. Time-frequency power and phase analyses can provide more detailed measures of brain dynamics of MMN deficits in schizophrenia. METHOD: 21 patients with schizophrenia and 21 healthy controls were tested with a roving frequency paradigm to generate MMN. Time-frequency domain power and phase-locking (PL) analysis was performed on all trials using short-time Fourier transforms with Hanning window tapering. A comprehensive battery (CANTAB) was used to assess neurocognitive functioning.

Original language	English
Article number	e83255
Number of pages	11
Journal	PLoS ONE
Volume	8
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0083255
Publication status	Published - 2013

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10.1371/journal.pone.0083255Licence: CC BY

2372757-oaFinal published version, 936 KBLicence: CC BY

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Kaser, M., Soltesz, F., Lawrence, P., Miller, S., Dodds, C. M., Croft, R. J., Dudas, R. B., Zaman, R., Fernandez-Egea, E., Muller, U., Dean, A. M., Bullmore, E., & Nathan, P. J. (2013). Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia. PLoS ONE, 8(12), Article e83255. https://doi.org/10.1371/journal.pone.0083255

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abstract = "Impairments in mismatch negativity (MMN) generation have been consistently reported in patients with schizophrenia. However, underlying oscillatory activity of MMN deficits in schizophrenia and the relationship with cognitive impairments have not been investigated in detail. Time-frequency power and phase analyses can provide more detailed measures of brain dynamics of MMN deficits in schizophrenia. METHOD: 21 patients with schizophrenia and 21 healthy controls were tested with a roving frequency paradigm to generate MMN. Time-frequency domain power and phase-locking (PL) analysis was performed on all trials using short-time Fourier transforms with Hanning window tapering. A comprehensive battery (CANTAB) was used to assess neurocognitive functioning.",

author = "Muzaffer Kaser and Fruzsina Soltesz and Philip Lawrence and Sam Miller and Dodds, \{Chris M\} and Croft, \{Rodney James\} and Dudas, \{Robert B\} and Rashid Zaman and Emilio Fernandez-Egea and Ulrich Muller and Dean, \{Anna M\} and Edward Bullmore and Nathan, \{Pradeep Jonathan\}",

year = "2013",

doi = "10.1371/journal.pone.0083255",

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T1 - Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia

AU - Kaser, Muzaffer

AU - Soltesz, Fruzsina

AU - Lawrence, Philip

AU - Miller, Sam

AU - Dodds, Chris M

AU - Croft, Rodney James

AU - Dudas, Robert B

AU - Zaman, Rashid

AU - Fernandez-Egea, Emilio

AU - Muller, Ulrich

AU - Dean, Anna M

AU - Bullmore, Edward

AU - Nathan, Pradeep Jonathan

PY - 2013

Y1 - 2013

N2 - Impairments in mismatch negativity (MMN) generation have been consistently reported in patients with schizophrenia. However, underlying oscillatory activity of MMN deficits in schizophrenia and the relationship with cognitive impairments have not been investigated in detail. Time-frequency power and phase analyses can provide more detailed measures of brain dynamics of MMN deficits in schizophrenia. METHOD: 21 patients with schizophrenia and 21 healthy controls were tested with a roving frequency paradigm to generate MMN. Time-frequency domain power and phase-locking (PL) analysis was performed on all trials using short-time Fourier transforms with Hanning window tapering. A comprehensive battery (CANTAB) was used to assess neurocognitive functioning.

AB - Impairments in mismatch negativity (MMN) generation have been consistently reported in patients with schizophrenia. However, underlying oscillatory activity of MMN deficits in schizophrenia and the relationship with cognitive impairments have not been investigated in detail. Time-frequency power and phase analyses can provide more detailed measures of brain dynamics of MMN deficits in schizophrenia. METHOD: 21 patients with schizophrenia and 21 healthy controls were tested with a roving frequency paradigm to generate MMN. Time-frequency domain power and phase-locking (PL) analysis was performed on all trials using short-time Fourier transforms with Hanning window tapering. A comprehensive battery (CANTAB) was used to assess neurocognitive functioning.

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U2 - 10.1371/journal.pone.0083255

DO - 10.1371/journal.pone.0083255

M3 - Article

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VL - 8

JO - PLoS ONE

JF - PLoS ONE

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ER -

Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia

Abstract

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