Orthostatic hypotension secondary to CRMP-5 paraneoplastic autonomic neuropathy

Andrew J. Neal; Mary Y. Qian; Alexandra S. Clinch; Brian H. Le

doi:10.1016/j.jocn.2013.07.035

Orthostatic hypotension secondary to CRMP-5 paraneoplastic autonomic neuropathy

Andrew J. Neal, Mary Y. Qian, Alexandra S. Clinch, Brian H. Le

Research output: Contribution to journal › Article › Other › peer-review

12 Citations (Scopus)

Abstract

The collapsin response mediator protein 5 (CRMP-5) autoantibody is one of only several paraneoplastic antibodies associated with autonomic neuropathy. Such paraneoplastic neuropathies manifest with a constellation of autonomic abnormalities. We present a unique case of orthostatic hypotension as the sole feature of a CRMP-5 paraneoplastic autonomic neuropathy in a patient with small cell lung cancer. Given the poor prognosis of paraneoplastic autonomic dysfunction, it is important to accurately diagnose the cause of orthostatic hypotension occurring on a background of malignancy.

Original language	English
Pages (from-to)	885-886
Number of pages	2
Journal	Journal of Clinical Neuroscience
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/j.jocn.2013.07.035
Publication status	Published - 1 Jan 2014
Externally published	Yes

Keywords

Autonomic neuropathy
CRMP-5
Orthostatic hypotension
Paraneoplastic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jocn.2013.07.035

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title = "Orthostatic hypotension secondary to CRMP-5 paraneoplastic autonomic neuropathy",

abstract = "The collapsin response mediator protein 5 (CRMP-5) autoantibody is one of only several paraneoplastic antibodies associated with autonomic neuropathy. Such paraneoplastic neuropathies manifest with a constellation of autonomic abnormalities. We present a unique case of orthostatic hypotension as the sole feature of a CRMP-5 paraneoplastic autonomic neuropathy in a patient with small cell lung cancer. Given the poor prognosis of paraneoplastic autonomic dysfunction, it is important to accurately diagnose the cause of orthostatic hypotension occurring on a background of malignancy.",

keywords = "Autonomic neuropathy, CRMP-5, Orthostatic hypotension, Paraneoplastic",

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T1 - Orthostatic hypotension secondary to CRMP-5 paraneoplastic autonomic neuropathy

AU - Neal, Andrew J.

AU - Qian, Mary Y.

AU - Clinch, Alexandra S.

AU - Le, Brian H.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The collapsin response mediator protein 5 (CRMP-5) autoantibody is one of only several paraneoplastic antibodies associated with autonomic neuropathy. Such paraneoplastic neuropathies manifest with a constellation of autonomic abnormalities. We present a unique case of orthostatic hypotension as the sole feature of a CRMP-5 paraneoplastic autonomic neuropathy in a patient with small cell lung cancer. Given the poor prognosis of paraneoplastic autonomic dysfunction, it is important to accurately diagnose the cause of orthostatic hypotension occurring on a background of malignancy.

AB - The collapsin response mediator protein 5 (CRMP-5) autoantibody is one of only several paraneoplastic antibodies associated with autonomic neuropathy. Such paraneoplastic neuropathies manifest with a constellation of autonomic abnormalities. We present a unique case of orthostatic hypotension as the sole feature of a CRMP-5 paraneoplastic autonomic neuropathy in a patient with small cell lung cancer. Given the poor prognosis of paraneoplastic autonomic dysfunction, it is important to accurately diagnose the cause of orthostatic hypotension occurring on a background of malignancy.

KW - Autonomic neuropathy

KW - CRMP-5

KW - Orthostatic hypotension

KW - Paraneoplastic

UR - http://www.scopus.com/inward/record.url?scp=84898599199&partnerID=8YFLogxK

U2 - 10.1016/j.jocn.2013.07.035

DO - 10.1016/j.jocn.2013.07.035

M3 - Article

C2 - 24268757

SN - 0967-5868

VL - 21

SP - 885

EP - 886

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

IS - 5

ER -

Orthostatic hypotension secondary to CRMP-5 paraneoplastic autonomic neuropathy

Abstract

Keywords

UN SDGs

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