Orthostatic hypotension secondary to CRMP-5 paraneoplastic autonomic neuropathy

Andrew J. Neal, Mary Y. Qian, Alexandra S. Clinch, Brian H. Le

Research output: Contribution to journalArticleOtherpeer-review

8 Citations (Scopus)


The collapsin response mediator protein 5 (CRMP-5) autoantibody is one of only several paraneoplastic antibodies associated with autonomic neuropathy. Such paraneoplastic neuropathies manifest with a constellation of autonomic abnormalities. We present a unique case of orthostatic hypotension as the sole feature of a CRMP-5 paraneoplastic autonomic neuropathy in a patient with small cell lung cancer. Given the poor prognosis of paraneoplastic autonomic dysfunction, it is important to accurately diagnose the cause of orthostatic hypotension occurring on a background of malignancy.

Original languageEnglish
Pages (from-to)885-886
Number of pages2
JournalJournal of Clinical Neuroscience
Issue number5
Publication statusPublished - 1 Jan 2014
Externally publishedYes


  • Autonomic neuropathy
  • CRMP-5
  • Orthostatic hypotension
  • Paraneoplastic

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