Orthogonally protected monosaccharide building blocks for solid phase production of diversity oriented libraries

Premraj Rajaratnam, Praveer Gupta, Peter Katavic, Krystle Kuipers, Ngoc Huyh, Sarah Ryan, Tania Falzun, Gerrald B. Tometzki, Laurent Bornaghi, Giang Le Thanh, Giovanni Abbenante, Ligong Liu, Wim Meutermans, Norbert Wimmer, Michael L. West

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

The large scale synthesis of three orthogonally protected monosaccharide scaffolds suitable for use in the solid phase preparation of large diversity libraries is presented. Scaffolds based on 2-amino-2-deoxy-d-glucopyranose, 2-amino-2-deoxy-d-allopyranose, and 2,4-diamino-2,4-dideoxy-d-galactopyranose were prepared in good yield and with minimal chromatographic purification from commercially available methyl 2-azido-2-deoxy-1-thio - d-glucopyranose and methyl 2-amino-2-deoxy-1-thio - d-glucopyranose.

Original languageEnglish
Pages (from-to)693-699
Number of pages7
JournalAustralian Journal of Chemistry
Volume63
Issue number4
DOIs
Publication statusPublished - 19 Apr 2010
Externally publishedYes

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