Orthogonal modification of norbornene-functional degradable polymers

Rebecca J. Williams, Ian A. Barker, Rachel K. OReilly, Andrew P. Dove

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)


Well-defined norbornene-functional poly(carbonate)s were prepared by ring-opening polymerization and utilized as multireactive polymeric scaffolds in a range of postpolymerization modifications. The norbornene-functional handles were shown to undergo facile reaction with azides via a 1,3-dipolar cycloaddition, tetrazines in the inverse electron demand Diels-Alder reaction and thiols via radical thiol-ene coupling. Furthermore, the above-mentioned chemistries were demonstrated in a sequential one-pot, three-step modification reaction illustrating the potential of these polymers as scaffolds to access multifunctionalized materials in an undemanding manner.

Original languageEnglish
Pages (from-to)1285-1290
Number of pages6
JournalACS Macro Letters
Issue number11
Publication statusPublished - 2012
Externally publishedYes

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