Projects per year
Abstract
Accumulating evidence indicates that adolescent endometriosis is common and often severe. Here we explore the possibility that seeding of naive endometrial progenitor cells into the pelvic cavity early in life, that is, at the time of neonatal uterine bleeding or soon after the menarche, results in more florid and progressive disease, characterized by highly angiogenic implants, recurrent ectopic bleeding, and endometrioma formation. We discuss the potential intergenerational risk factors associated with early-onset endometriosis and explore the molecular drivers of disease progression. Taken together, the available data suggest that an increased focus on early-life events may help to identify young women at risk of severe, progressive endometriosis.
Original language | English |
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Pages (from-to) | 1282-1288 |
Number of pages | 7 |
Journal | Reproductive Sciences |
Volume | 23 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Oct 2016 |
Keywords
- adolescent endometriosis
- endometrioma
- progression
- stem cells
Projects
- 1 Finished
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NHMRC Research Fellowship
National Health and Medical Research Council (NHMRC) (Australia)
1/01/13 → 31/12/18
Project: Research