Original article predictive accuracy and sources of variability in calculated free testosterone estimates

Gideon Sartorius; Lam P. Ly; Ken Sikaris; Robert McLachlan; David J. Handelsman

doi:10.1258/acb.2008.008171

Original article predictive accuracy and sources of variability in calculated free testosterone estimates

Gideon Sartorius, Lam P. Ly, Ken Sikaris, Robert McLachlan, David J. Handelsman

Research output: Contribution to journal › Article › Research › peer-review

162 Citations (Scopus)

Abstract

Background: Serum free testosterone (FT) concentrations are commonly requested, but because reference FT methods are too laborious various calculational algorithms for FT based on total testosterone (TT) and sex hormone-binding globulin (SHBG) are frequently used. This study provides the first large-scale evaluation of the predictive accuracy and sources of variability for different FT formulae compared with direct laboratory measurements.

Original language	English
Pages (from-to)	137-143
Number of pages	7
Journal	Annals of Clinical Biochemistry
Volume	46
Issue number	2
DOIs	https://doi.org/10.1258/acb.2008.008171
Publication status	Published - Mar 2009
Externally published	Yes

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10.1258/acb.2008.008171

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title = "Original article predictive accuracy and sources of variability in calculated free testosterone estimates",

abstract = "Background: Serum free testosterone (FT) concentrations are commonly requested, but because reference FT methods are too laborious various calculational algorithms for FT based on total testosterone (TT) and sex hormone-binding globulin (SHBG) are frequently used. This study provides the first large-scale evaluation of the predictive accuracy and sources of variability for different FT formulae compared with direct laboratory measurements.",

author = "Gideon Sartorius and Ly, \{Lam P.\} and Ken Sikaris and Robert McLachlan and Handelsman, \{David J.\}",

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AU - Sartorius, Gideon

AU - Ly, Lam P.

AU - Sikaris, Ken

AU - McLachlan, Robert

AU - Handelsman, David J.

PY - 2009/3

Y1 - 2009/3

N2 - Background: Serum free testosterone (FT) concentrations are commonly requested, but because reference FT methods are too laborious various calculational algorithms for FT based on total testosterone (TT) and sex hormone-binding globulin (SHBG) are frequently used. This study provides the first large-scale evaluation of the predictive accuracy and sources of variability for different FT formulae compared with direct laboratory measurements.

AB - Background: Serum free testosterone (FT) concentrations are commonly requested, but because reference FT methods are too laborious various calculational algorithms for FT based on total testosterone (TT) and sex hormone-binding globulin (SHBG) are frequently used. This study provides the first large-scale evaluation of the predictive accuracy and sources of variability for different FT formulae compared with direct laboratory measurements.

UR - https://www.scopus.com/pages/publications/64549120309

U2 - 10.1258/acb.2008.008171

DO - 10.1258/acb.2008.008171

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AN - SCOPUS:64549120309

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VL - 46

SP - 137

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JO - Annals of Clinical Biochemistry

JF - Annals of Clinical Biochemistry

IS - 2

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Original article predictive accuracy and sources of variability in calculated free testosterone estimates

Abstract

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