Origin of broad polydispersion in functionalized dendrimers and its effects on cancer-cell binding affinity

Jack N. Waddell, Douglas G. Mullen, Bradford G. Orr, Mark M. Banaszak Holl, Leonard M. Sander

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Nanoparticles with multiple ligands have been proposed for use in nanomedicine. The multiple targeting ligands on each nanoparticle can bind to several locations on a cell surface facilitating both drug targeting and uptake. Experiments show that the distribution of conjugated ligands is unexpectedly broad, and the desorption rate appears to depend exponentially upon the mean number of attached ligands. These two findings are explained with a model in which ligands conjugate to the nanoparticle with a positive cooperativity of 4kT, and that nanoparticles bound to a surface by multiple bonds are permanently affixed. This drives new analysis of the data, which confirms that there is only one time constant for desorption, that of a nanoparticle bound to the surface by a single bond.

Original languageEnglish
Article number036108
JournalPhysical Review E
Volume82
Issue number3
DOIs
Publication statusPublished - 15 Sep 2010
Externally publishedYes

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