Organosilica particles for DNA screening applications

Simon Corrie, Gwen Lawrie, Bronwyn Battersby, Matt Trau

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther


Particle-based libraries for chemical screening are of interest for robust biochemical assays and molecular diagnostic applications. Silica particles are chemically stable and possess two separate chemical modification pathways that facilitate the attachment of fluorescent dyes for encoding purposes and specific oligonucleotides for hybridization assays. Characterization of surface modifications of the particles are presented and quantitation of oligonucleotide probes on the particle surface is described. The application of the particles in biological screening experiments is presented by means of a single base mismatch detection assay.

Original languageEnglish
Title of host publicationProceedings of the 2006 International Conference on Nanoscience and Nanotechnology, ICONN
Number of pages4
Publication statusPublished - 1 Dec 2006
Externally publishedYes
EventInternational Conference on Nanoscience and Nanotechnology (ICONN) 2006 - Brisbane, Australia
Duration: 3 Jul 20066 Jul 2006
Conference number: 1st


ConferenceInternational Conference on Nanoscience and Nanotechnology (ICONN) 2006
Abbreviated titleICONN 2006


  • 3-Mercaptopropyl trimethoxysilane
  • DNA hybridization
  • Flow cytometry
  • Particles
  • Surface modifications

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